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Oxidative Stress Biomarkers and Incidence of Postoperative Atrial Fibrillation in the Omega-3 Fatty Acids for Prevention of Postoperative Atrial Fibrillation (OPERA) Trial

Jason H Y Wu,Roberto Marchioli,Maria G Silletta,Serge Masson,Frank W Sellke,Peter Libby,Ginger L Milne,Nancy J Brown,Federico Lombardi,Ralph J Damiano,Joann Marsala,Mauro Rinaldi,Alberto Domenech,Caterina Simon,Luigi Tavazzi, and Dariush Mozaffarian

Jason H Y Wu

George Institute for Global Health, Sydney Medical School, The University of Sydney, New South Wales, Australia (J.H.Y.W.)

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Roberto Marchioli

Hematology-Oncology Therapeutic Delivery Unit, Quintiles, Milan, Italy (R.M.)

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Maria G Silletta

Laboratory of Clinical Epidemiology of Cardiovascular Disease, Fondazione Mario Negri Sud, Santa Maria Imbaro, Italy (M.G.S.)

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Serge Masson

Department of Cardiovascular Research, IRCCS—Istituto di Ricerche Farmacologiche “Mario Negri”, Milan, Italy (S.M.)

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Frank W Sellke

Division of Cardiothoracic Surgery, Cardiovascular Research Center, Brown University Warren Alpert School of Medicine, Providence, RI (F.W.S.)

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Peter Libby

Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA (P.L.)

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Ginger L Milne

Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN (G.L.M.)

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Nancy J Brown

Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (N.J.B.)

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Federico Lombardi

U.O.C. di Malattie Cardiovascolari, Fondazione IRCCS Ospedale Maggiore Policlinico, Dipartimento di Scienze Cliniche e di Communita, Universita degli Studi di Milano, Italy (F.L.)

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Ralph J Damiano

Division of Cardiothoracic Surgery, Washington University School of Medicine, St Louis, MO (R.J.D., J.M.)

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Joann Marsala

Division of Cardiothoracic Surgery, Washington University School of Medicine, St Louis, MO (R.J.D., J.M.)

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Mauro Rinaldi

Division of Cardiac Surgery, Citta’della Salute e della Scienza, University of Turin, Italy (M.R.)

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Alberto Domenech

Department of Cardiovascular Surgery, Italian Hospital of Buenos Aires, Argentina (A.D.)

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Caterina Simon

Cardiovascular Department, Cardiac Surgery, Ospedali Riuniti di Bergamo, Italy (C.S.)

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Luigi Tavazzi

Maria Cecilia Hospital, GVM Care & Research—E.S. Health Science Foundation, Cotignola, Italy (L.T.)

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Dariush Mozaffarian

Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (D.M.)

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Author informationArticle notesCopyright and License informationDisclaimer

George Institute for Global Health, Sydney Medical School, The University of Sydney, New South Wales, Australia (J.H.Y.W.)

Hematology-Oncology Therapeutic Delivery Unit, Quintiles, Milan, Italy (R.M.)

Laboratory of Clinical Epidemiology of Cardiovascular Disease, Fondazione Mario Sketchup pro 2019 serial number and authorization code - Free Activators Sud, Santa Maria Imbaro, Italy (M.G.S.)

Department of Cardiovascular Research, IRCCS—Istituto di Ricerche Farmacologiche “Mario Negri”, Milan, Italy (S.M.)

Division of Cardiothoracic Surgery, Cardiovascular Research Center, Brown University Warren Alpert School of Medicine, Providence, RI (F.W.S.)

Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA (P.L.)

Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN (G.L.M.)

Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (N.J.B.)

U.O.C. di Malattie Cardiovascolari, Fondazione IRCCS Ospedale Maggiore Policlinico, Dipartimento di Scienze Cliniche e di Communita, Universita degli Studi di Milano, Italy (F.L.)

Division of Cardiothoracic Surgery, Washington University School of Medicine, St Louis, MO (R.J.D., J.M.)

Division of Cardiac Surgery, Citta’della Salute e della Scienza, University of Turin, Italy (M.R.)

Department of Cardiovascular Surgery, Italian Hospital of Buenos Aires, Argentina (A.D.)

Cardiovascular Department, Cardiac Surgery, Ospedali Riuniti di Bergamo, Italy (C.S.)

Maria Cecilia Hospital, GVM Care & Research—E.S. Health Science Foundation, Cotignola, Italy (L.T.)

Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (D.M.)

Correspondence to: Jason H. Y. Wu, PhD, Level 10, King George V Building, 83-117 Missenden Rd, Camperdown, NSW 2050, Australia. E-mail: ua.gro.etutitsniegroeg@1uwj

Accompanying Tables S1 through S3 are available at http://jaha.ahajournals.org/content/4/5/e001886/suppl/DC1

Received 2015 Feb 3; Accepted 2015 Apr 11.

Copyright © 2015 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

This article has been cited by other articles in PMC.

Supplementary Materials

Table S1. Concentrations and Unadjusted Spearman Correlation Coefficients for Plasma and Urine Concentration of Oxidative Stress Biomarkers in the OPERA Trial*

Table S2. Multivariable-Adjusted Risk of Postoperative Atrial Fibrillation According to Plasma Oxidative Stress Biomarkers in the OPERA Trial*

Table S3. Multivariable-Adjusted Risk of Postoperative Atrial Fibrillation According to Creatinine-Adjusted Urine Oxidative Stress Biomarkers in the OPERA Trial*

jah30004-e001886-sd1.pdf (80K)

GUID: 2BCA5622-8080-43A7-99B0-55D603B3DFF1

Abstract

Background

Animal study results point to oxidative stress as a key mechanism triggering postoperative atrial fibrillation (PoAF), yet the extent to which specific biomarkers of oxidative stress might relate to PoAF risk in humans remains speculative.

Methods and Results

We assessed the association of validated, fatty acid–derived oxidative stress biomarkers (F2-isoprostanes, isofurans, and F3-isoprostanes) in plasma and urine, with incident PoAF among 551 cardiac surgery patients. Biomarkers were measured at enrollment, the end of surgery, and postoperative day 2. PoAF lasting ≥30 seconds was confirmed with rhythm strip or electrocardiography and centrally adjudicated. Outcomes were assessed until hospital discharge or postoperative day 10, whichever occurred first. Urine level of each oxidative stress biomarker rose at the end of surgery (2- to 3-fold over baseline, P<0.001) and subsequently declined to concentrations comparable to baseline by postoperative day 2. In contrast, vsdc video editor pro review - Crack Key For U concentrations remained relatively stable throughout the perioperative course. Urine F2-isoprostanes and isofurans at the end of surgery were 20% and 50% higher in subjects who developed PoAF (P≤0.009). While baseline biomarker levels did not associate significantly with PoAF, end of surgery and postoperative day 2 isoprostanes and isofurans demonstrated relatively linear associations with PoAF. For example, the end of surgery extreme quartile multivariate adjusted OR (95% CI) for urine isofurans and F3-isoprostanes were 1.95 (1.05 to 3.62; P for trend=0.01) and 2.10 (1.04 to 2.25, P for trend=0.04), respectively. The associations of biomarkers with PoAF varied little by demographics, surgery type, and medication use (P≥0.29 for each).

Conclusions

These novel results add to accumulating evidence supporting the likely key pathogenic role of elevated oxidative stress in PoAF.

Keywords: atrial fibrillation, cardiac surgery, isofurans, isoprostanes, oxidative stress

Postoperative atrial fibrillation (PoAF) commonly complicates cardiac surgery. PoAF increases the risk of thromboembolic events, prolongs hospital care, increases healthcare costs, and elevates long-term mortality.1 Current frontline therapy such as β-blockers and amiodarone only partly prevent PoAF, likely reflecting the complex, multifactorial pathogenesis of PoAF.2 Improved understanding of the precise molecular and physiologic mechanisms contributing to PoAF could promote the development of novel targeted interventions.

Experimental evidence suggests oxidative stress can contribute to the pathogenesis of PoAF.2 Oxidative stress occurs when excess production of reactive oxygen species (ROS) overwhelms endogenous antioxidant defenses, resulting in tissue injury. In animal studies, oxidative stress contributed to cardiac myocyte dysfunction, electrical and structural remodeling, and the development of AF.35 Furthermore, oxidative stress could potentiate PoAF via activation of stress signaling pathways and inflammatory responses, which in turn amplify tissue injury.6,7 Evidence supporting the relationship between oxidative stress and PoAF in humans, however, remains limited. Studies based on analyses of human atrial tissues collected during cardiac surgery suggest a pathogenic role of oxidative stress and, in particular, identified elevated atrial nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity as associated with PoAF.8,9 Conversely, measurements of circulating oxidative stress biomarkers have yielded mixed findings,911 although such studies typically assessed oxidative stress by using biomarkers with low sensitivity and specificity, which could obscure potential associations.12 Furthermore, although levels of oxidative stress vary throughout the perioperative time course,13 there is a lack of comprehensive evaluation of the relationship of oxidative stress with PoAF at different cardiac surgery time points.

To investigate further the role of oxidative stress in PoAF, we tested the hypothesis that plasma and urine levels of F2-isoprostanes (F2-isoP), isofurans (IsoF), and F3-isoprostanes (F3-IsoP) associate with incident PoAF in a subset of 551 subjects in the Omega-3 Fatty Acids for Prevention of Post-Operative Atrial Fibrillation (OPERA) trial.14 F2-isoP, IsoF, and F3-IsoP are highly sensitive and robust lipid oxidation biomarkers derived from arachidonic acid (F2-isoP and IsoF) and eicosapentaenoic acid (F3-IsoP).15,16 Concentrations of these biomarkers were Opera 55.0 Build - Crack Key For U at baseline (ie, at study recruitment, representing baseline ambulatory levels of oxidative stress), at the end of cardiac surgery (reflecting acute changes in oxidative damage following ischemia–reperfusion), and again at postoperative day 2 (to capture trends in persistently elevated or oxidative stress or, conversely, return to homeostasis).

Methods

Design and Population

This investigation was designed as an ancillary study of the OPERA trial, which was a randomized, placebo-controlled study that found perioperative fish oil supplementation did not reduce PoAF.14 Design of the OPERA study has been reported in detail previously.17,18 In brief, the study enrolled 1516 patients from 28 medical centers undergoing cardiac surgery in 3 countries (United States, Italy, and Argentina). The inclusion criteria were broad: age ≥18 years, presence of sinus rhythm on the screening electrocardiogram (ECG), and being scheduled for cardiac surgery on the following day or later. Exclusions were absence of sinus rhythm at screening, regular use of fish oil, known intolerance or allergy to fish oil or olive oil (placebo), unable or unwilling to provide informed consent, being currently pregnant, or having an existing or a planned cardiac transplant or use of ventricular assist device. All participants provided written informed consent, and the study was approved by the human subjects committees of all participating institutions. Seventeen study centers participated in this ancillary study.

Oxidative Stress Biomarkers

EDTA-anticoagulated fasting blood and spot urine samples were collected from subjects with the use of standardized kits and techniques at baseline, the end of cardiac surgery, and postoperative day 2. Biologic samples were stored at −70°C at each study center and subsequently transferred on dry ice to a central sample bank for long-term storage at −80°C. After completion of the OPERA study, oxidative stress biomarkers were measured at the Eicosanoid Core Laboratory at Vanderbilt University with the use of highly robust and specific gas chromatography–mass spectrometry.19 Limits of detection were 1, 5, and 10 pg/mL for F2-IsoP, F3-Iso, and IsoF, respectively. Interassay coefficient of variations were ≤15%. Levels of oxidative stress biomarkers in plasma are reported in picograms per milliliter, whereas their levels in urine are normalized to creatinine clearance and reported as nanograms per milligrams of creatinine. We were unable to quantify oxidative stress biomarkers in a small portion of samples (≤2% for F2-IsoP and IsoF, ≤12% for F3-IsoP) due to coeluting contaminants, and these samples were thus excluded from the analyses. If the level of an oxidative stress biomarker in a sample was less than the assay detection limit, its value was imputed as half of the detection limit.

Covariates

Other potential risk factors for PoAF were assessed by using standardized methods including demographics, lifestyle behaviors, cardiovascular risk factors, anthropometric measurements, medical and surgical history, comorbidities, medication use (outpatient and inpatient), echocardiographic evaluation, and laboratory measures. Additional data were collected regarding surgical procedure and daily follow-up and discharge information.

Outcomes

A centralized events committee of cardiac electrophysiologists reviewed and adjudicated all suspected episodes of PoAF, based on documentations including duration, clinical information, and confirmatory rhythm strip or 12-lead ECG. The primary end point for this analysis is incident PoAF of ≥30 seconds’ duration, with outcomes assessed until hospital discharge or postoperative day 10, whichever occurred first.

Statistical Analysis

The interrelationships between individual oxidative stress biomarkers were assessed at each time point by using Spearman correlation coefficients. Changes in biomarker level between study time points were assessed with paired t test. Oxidative stress biomarker concentrations were evaluated in quartiles as indicator variables, and their associations with incident PoAF were investigated by using multivariable-adjusted logistic regression. Biomarkers were also examined as continuous variables after log transformation because these variables were right-skewed. Tests of linear trend were conducted by assigning to participants the median value in each quartile and assessing this as a single continuous variable. We also examined possible nonlinear relationships between circulating and urine biomarkers and risk of PoAF nonparametrically by using restricted cubic splines, after excluding participants with extreme values (<1st or >99th percentile) to minimize the effects of outliers. To minimize confounding, we adjusted for age, sex, country, body mass index, prevalent hypertension, prevalent diabetes, prevalent coronary heart disease, prevalent chronic renal failure, prevalent heart failure, smoking, dyslipidemia, statin medication use, left ventricular ejection fraction, and logistic Euroscore.20 Adjustment for treatment did not make a difference and was not included in the final model. Missing covariates (<3%) were singly imputed by best-subset-regression with demographic/risk variables. Results were similar excluding those with missing covariate values. In sensitivity analyses, we also assessed the association between changes in oxidative stress biomarker concentrations from baseline to end of surgery and PoAF.

Effect modification were evaluated in stratified analyses for several subgroups including age (<median, ≥median), sex, country, adobe premiere pro iso - Activators Patch mass index (<median, ≥median), type of surgery (valve surgery versus nonvalve surgery), smoking (current versus ex-smokers and nonsmokers), aspirin use, and statin use. For each subgroup, oxidative stress biomarkers were assessed in stratum-specific quartiles as indicator variables. The significance of potential effect modification was tested by using the Wald test for a multiplicative interaction term between the biomarker quartiles (evaluated as ordinal variables) and the stratification variable, with Bonferroni-corrected α level to account for multiple comparisons. All P values were 2-tailed (α=0.05), and analyses were performed with Stata 13.1 (Stata Corp).

Results

The mean age of the participants was 63 years, and the majority (72%) were men (Table1). Subjects were enrolled in the United States (57%), Italy (32%), and Argentina (11%). As expected, there was a high prevalence of cardiometabolic risk factors, including hypertension and dyslipidemia, and nearly 50% of the subjects have a history of coronary heart disease.

Table 1

Baseline Characteristics of Subjects With Oxidative Stress Biomarker Measures in the OPERA Trial (N=551)

CharacteristicsSummary Statistics*
Country, %
 USA57.0
 Italy32.1
 Argentina10.9
Age, y62.7±12.7
Sex, % male72.2
Planned valve surgery, %55.0
Planned CABG, %48.3
Current smoking, %13.3
Diabetes mellitus, %29.8
Body mass index, kg/m229.0±6.1
Hypertension, %77.1
COPD, %14.3
Dyslipidemia, %64.1
Chronic renal failure, %6.5
Coronary heart disease, %44.5
Prior myocardial infarction, %22.9
Prior PCI, %14.5
Prior arrhythmias, %13.8
Prior atrial fibrillation, %8.0
Congestive heart failure, EssentialPIM Pro Activation Key rowspan="1" colspan="1">20.0
Ejection fraction, %56.2±11.2
β-Blocker, %54.1
Statins, %56.6
ACE inhibitor, %35.6
Aspirin, %61.9
Antiarrhythmics, %4.4
Logistic Euroscore, units6.2±7.5

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The levels of individual oxidative stress biomarkers and their correlations are shown in the online supplemental data (Table S1). While the concentrations of F2-IsoP and IsoF were similar, they were an order of magnitude larger than F3-Iso in both plasma and urine. Biomarkers measured in the same compartment (plasma or urine) showed moderate to high correlations, with the strongest associations observed for F2-IsoP and IsoF. For example, Spearman correlation coefficients at the end of cardiac surgery were between 0.43 and 0.72 among urine oxidative stress biomarkers (P<0.001 for each); conversely, plasma concentrations of each biomarker correlated either not Metal Gear Solid V The Phantom Pain PC Crack Torrent Download {2021} all or only weakly with their respective urine levels. For example, plasma and urine isofurans did not correlate significantly at any of the time points assessed (r = −0.05 to 0.05, P≥0.32 for each).

There were significant changes in the concentrations of oxidative stress biomarkers aftert cardiac surgery, with distinct patterns for plasma and urine measurements, as well as for subjects who did or did not develop PoAF (Figures​1 and ​2). One of the most pronounced change was the 2- to 3-fold increase over baseline in urine level of all 3 oxidative stress biomarkers following cardiac surgery (P<0.001 for each). Furthermore, at the end of surgery, F2-isoP and IsoF levels were ≈20% and ≈50% higher in subjects who subsequently developed PoAF (P≤0.009, adjusted for enrollment biomarker concentrations). At postoperative day 2, urine levels of all 3 biomarkers fell significantly (paired t test relative to end of surgery, P≤0.03 for each), to concentrations comparable to baseline. Plasma levels of oxidative stress biomarkers did not show such marked variation as urine concentrations throughout the study. At postoperative day 2, levels of F2-IsoP and IsoF were slightly lower relative to the end of surgery (≈10%, P≤0.04 for each), and F2-IsoP levels were ≈20% higher in subjects who developed PoAF than in those who did not (P=0.05). Plasma F3-Iso was higher at the end of cardiac surgery (≈40%, P<0.001) and remained similar at postoperative day 2.

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Object name is jah30004-e001886-f1.jpg

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Figure 1

Plasma oxidative stress biomarkers concentration (pg/mL) at baseline (recruitment), end of surgery (at time of closure), and postoperative day 2. Data shown are mean±SE. The white and gray bars represent subjects without and with incident postoperative atrial fibrillation (PoAF), respectively. *Mean plasma level of F2-isoprostanes were ≈20% higher in patients who developed PoAF than in those who did not (P=0.05, adjusted for end of surgery F2-isoprostane concentrations).

An external file that holds a picture, illustration, etc.
Object name is jah30004-e001886-f2.jpg

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Figure 2

Urine creatinine-adjusted concentration of oxidative stress biomarkers (ng/mg) at baseline (recruitment), end of surgery (at time of closure), and postoperative day 2. Data shown are mean±SE. The white and gray bars represent subjects without and with incident postoperative atrial fibrillation (PoAF), respectively. *Mean urine F2-isoprostane and isofuran levels were ≈20% and ≈50% higher in subjects who subsequently developed PoAF (P≤0.009, adjusted for baseline concentrations).

Among the 551 subjects in the study, 171 developed PoAF during follow-up. Oxidative stress biomarkers in plasma or urine at baseline did not associate significantly with PoAF (online supplemental data, Tables S2 and S3). By the end of surgery, however, the concentrations of IsoF in urine and plasma associated with elevated risk of PoAF. For example, the OR (95% CI) for participants in the highest compared with the lowest quartile of urine IsoF was 1.95 (1.05 to 3.62, P for trend=0.01). Urine, but not plasma F3-IsoP, concentration also associated with higher PoAF risk, with extreme quartile OR (95% CI) of 2.10 (1.04 to 2.25, P for trend=0.04). F2-IsoP at the end of surgery did not associate with PoAF. At postoperative day 2, plasma F2-IsoP and IsoF both associated with higher PoAF risk, with extreme quartile OR (95% CI) of 2.53 (1.14 to 5.58) microsoft office 2016 free download full version for windows 10 - Crack Key For U 2.98 (1.22 to 7.25), respectively. Urine concentrations of these biomarkers did not significantly associate with PoAF. Similarly, levels of F3-IsoP at postoperative day 2 in urine and plasma were not associated with subsequent PoAF. Semiparametric analyses with restricted cubic splines suggested relatively linear (monotonic) associations of oxidative stress biomarkers at the end of surgery and postoperative day 2 with incident PoAF (Figures​3 and ​4).

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Figure 3

Multivariable-adjusted association of plasma (A) isofuran at end of surgery (B) isofuran at postoperative day 2 and (C) F2-isoprostanes at postoperative day 2 with postoperative atrial fibrillation (PoAF), evaluated by restricted cubic splines and logistic regression. Biomarkers underwent log-transformation before analyses as they were right-skewed, and analyses adjusted for age (years), sex (male/female), country (US, Italy, Argentina), body mass index (kg/m2), prevalent hypertension (yes/no), prevalent diabetes (yes/no), prevalent coronary heart disease (yes/no), prevalent chronic renal failure (yes/no), prevalent heart failure (yes/no), smoking (never or former/current), dyslipidemia (yes/no), statin medication use (yes/no), ejection fraction (%), and logistic Euroscore (continuous). The solid red line and shaded areas represent the OR and 95% CIs, respectively, in comparison to the reference level representing the median value of the lowest quartile (12.5th percentile). Dotted vertical lines correspond to the 10th, 25th, 50th, 75th, and 90th percentiles of the log biomarker concentrations. There was overall linear association for each biomarkers with PoAF (P≤0.02) but little evidence of nonlinearity (P≥0.83).

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Figure 4

Multivariable-adjusted association of end of surgery (A) urine isofurans and (B) urine F3-isoprostanes with postoperative atrial fibrillation (PoAF), evaluated by restricted cubic splines and logistic regression. Biomarkers underwent log-transformation before analyses as they were right-skewed, and analyses adjusted for age (years), sex (male/female), country (US, Italy, Argentina), body mass index (kg/m2), prevalent hypertension (yes/no), prevalent diabetes (yes/no), prevalent coronary heart disease (yes/no), prevalent chronic renal failure (yes/no), prevalent heart failure (yes/no), smoking (never or former/current), dyslipidemia (yes/no), statin medication use (yes/no), ejection fraction (%), and logistic Euroscore (continuous). The solid red line and shaded areas represent the OR and 95% CIs, respectively, in comparison to the reference level representing the median value of the lowest quartile (12.5th percentile). Dotted vertical lines correspond to the 10th, 25th, 50th, 75th, and 90th percentiles of the log biomarker concentrations. Both biomarkers associated linearly overall with PoAF (P=0.02 for each) but showed little evidence of nonlinearity (P≥0.26 for each).

Results were similar when the biomarkers were assessed continuously. For example, each doubling of urine IsoF at the end of surgery was associated with an OR (95% CI) of 1.20 (1.03 to 1.41, P=0.02). In sensitivity analyses, changes in plasma and urine oxidative stress biomarker concentration from baseline to the end of surgery showed similar direction and magnitude of association with PoAF as end of surgery levels alone (not shown). Further adjustment for study treatment, valve surgery, time on pump, prevalent obstructive pulmonary disease, antiarrhythmic medication, changes in white blood cell count, and aspirin use did not appreciably alter the results (not shown). There was little evidence that country, age, sex, body mass index, type of surgery, smoking, and aspirin and statin use significantly modified the association of oxidative stress biomarkers and PoAF (Bonferroni corrected, P for interaction ≥0.29 for each).

Discussion

In this prospective cohort study of cardiac surgery patients, higher end of surgery and postoperative oxidative stress assessed by F2-IsoP, IsoF, and F3-IsoP associated independently with elevated risk of PoAF. The magnitude of associations was substantial, and subjects in the top quartile of lipid peroxidation biomarker had up to 3-fold higher odds of PoAF. In contrast, baseline IsoP and IsoF did not associate with PoAF.

Accumulating experimental evidence supports the biologic plausibility of these findings by indicating a causal role of oxidative stress in pathologic atrial structural remodeling, abnormal ion channel function, and increased vulnerability to AF.21 In animals, risk factors for AF development, such as hypertension and heart failure, link with increased ROS production,22,23 and treatment with antioxidants reduces atrial fibrosis and prevents tissue oxidative damage and occurrence of Acme cad converter 2019 - Crack Key For U Arachidonic acid and eicosapentaenoic acids in cardiac membranes may also influence AF development.27 Structural modification of these polyunsaturated fatty acids by ROS to IsoP and IsoF may disrupt their capacity to regulate protein and ion channel functions.28 Furthermore, not only do IsoP and IsoF serve as sensitive biomarkers of oxidative stress in vivo; they also may contribute to inflammation, such as by enhancing adhesion of monocytes to endothelial cells.29,30

The observed increase in urine F2-IsoP, IsoF, and F3-IsoP between baseline and the end of surgery is consistent with cardiac surgery–induced oxidative stress.31 Our data also indicate the transience of the imbalance in ROS generation and antioxidant defense triggered by cardiac surgery, as levels of urine biomarkers fell to near baseline levels by postoperative day 2. Whereas urine levels of these oxidative stress biomarkers provide a time-integrated measure of subacute systemic oxidative stress, their plasma levels reflect acute systemic oxidative stress, due to their rapid metabolism and renal excretion,32 which may explain the relative stability of plasma levels of these biomarkers observed in our study. Urine IsoF demonstrated a relatively greater increase than IsoP. Although both IsoF and IsoP arise from ROS-mediated peroxidation of polyunsaturated fatty acids, mitochondrial dysfunction and elevated oxygen concentration favor formation of IsoF.16 Our results, therefore, highlight the likely importance of identifying not only endogenous sources of oxidative stress but also factors that expose patients to increased oxygen concentration, such as inspired oxygen supplementation during cardiac surgery.

Our investigation demonstrates that higher oxidative stress at postoperative day 2 associates with subsequent risk of PoAF. These findings highlight the need to identify therapies that could reduce oxidative stress throughout the perioperative time course, specifically targeting oxidants that may cause lipid oxidation. Increasing evidence suggest both statins, which downregulate NADPH oxidase,33 and antioxidant scavengers are of potential interest, and recent meta-analyses of controlled trials found supplementation with statins or putative antioxidants (eg, vitamin C) reduced the risk of PoAF.34,35 However, these findings should be interpreted with caution given the large heterogeneity observed between the results of individual trials and the lack of evidence that the treatments actually reduced oxidative stress in vivo.35 Our findings indicate that future trials could rationally determine the dose and duration of statin or antioxidant therapy for PoAF prevention, based on their ability to reduce plasma or urine IsoP and IsoF. Because oxidative stress may activate inflammation, future studies should also examine inflammatory biomarkers (eg, myeloperoxidase), which could provide additional information.6,36

Our study has important strengths. The use of highly sensitive and specific IsoP and IsoF, assessed across multiple perioperative time points allowed comprehensive evaluation of the relationships of lipid oxidation and PoAF, and inclusion of these complementary biomarkers provide additional insight into potential oxidative stress mechanisms. The study used highly accurate and reproducible assays to measure the biomarkers, limiting the likelihood of misclassification of these exposures. The prospective design minimized selection bias and enabled inference on temporality of associations. Careful collection of information on many potential covariates allowed detailed adjustment to control for confounding. A centralized events committee conducted careful adjudication of PoAF events that lowered the possibility of outcome misclassification. Subjects in the OPERA trial were from different countries with varied demographic and lifestyle characteristics, which enhances generalizability.

Potential limitations also merit consideration. While IsoP and IsoF quantify the extent of lipid peroxidation, they do not provide insight into oxidative damage to other cellular compartments such as proteins and DNA, and these should be assessed in the future by using other validated biomarkers. We adjusted for a range of important demographic and clinical risk factors, but we cannot exclude the possibility of residual confounding due to unmeasured or imprecisely measured factors. Only a subset of OPERA trial subjects participated in this biologic study, which reduced statistical power. Nevertheless, this current investigation represents by far the largest study assessing objective, validated oxidative stress biomarkers in cardiac surgery patients. Although results from this study are relevant to cardiac surgery patients, findings may not be applicable to other populations at risk of AF. Of course, the strong association demonstrated by these data cannot establish causality between oxidative stress and the advent of PoAF. Yet, the grounds for biological plausibility mentioned here do support a causal link between oxidative stress and PoAF. Finally, our findings suggest the need to carefully evaluate the effect of fish oil treatment on oxidative stress levels in future studies.

In summary, cardiac surgery induce acute increase in oxidative stress as assessed with urine levels of IsoP and IsoF. In addition, elevated end of surgery and postoperative levels of these oxidative stress biomarkers relate to higher risk of PoAF. These novel results adds to growing evidence supporting the likely key pathogenic role of elevated oxidative stress in PoAF and suggest that further development of therapies targeting oxidative stress pathways for the prevention of PoAF is warranted.

Sources of Funding

This work was supported by the National Heart, Lung, and Blood Institute, National Institutes of Health (1 RC2 HL101816, and R01HL085710); GlaxoSmithKline; Sigma Tau; and Pronova BioPharma. The funding organizations had no role in the design, conduct, or analysis of the OPERA trial or this biologic substudy. The authors thank all OPERA participants.

Disclosures

Dr Mozaffarian reports ad hoc travel reimbursement or honoraria from Bunge, Pollock Institute, Quaker Oats, and Life Sciences Research Organization; ad hoc consulting fees from McKinsey Health Systems Institute, Foodminds, Nutrition Impact, Amarin, Omthera, and Winston and Strawn LLP; membership, Unilever North America Scientific Advisory Board; royalties from UpToDate; and research grants from the National Institutes of Health. The other authors report no conflicts.

Supporting Information

Table S1. Concentrations and Unadjusted Spearman Correlation Coefficients for Plasma and Urine Concentration of Oxidative Stress Biomarkers in the OPERA Trial*

Table S2. Multivariable-Adjusted Risk of Postoperative Atrial Fibrillation According to Plasma Oxidative Stress Biomarkers in the OPERA Trial*

Table S3. Multivariable-Adjusted Risk of Postoperative Atrial Fibrillation According to Creatinine-Adjusted Urine Oxidative Stress Biomarkers in the OPERA Trial*

Click here to view.(80K, pdf)

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Articles from Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease are provided here courtesy of Wiley-Blackwell


Источник: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599415/

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Helper8.4.8gltfquicklookGLTFQuickLook0.3.0gluemotionGlueMotion2.0.1,6055glyphfinderGlyphfinder1.4.1glyphsGlyphs3.0.4,3100gmail-notifierGmail Notifier2.1.0gmvaultGmvault1.9.1gns3GNS32.2.27gnucashGnuCash4.8-2go-agentGo Agent21.3.0,13067go-serverGo Server21.3.0,13067go2shellGo2Shell2.5,25go64Go641.3,1301gobdokumenteGoBDokumente1.6.8godotGodot Engine3.4godot-monoGodot Engine3.4gog-galaxyGOG Galaxy2.0.43.66agogsGo Git Service0.12.3golandGoland2021.2.4,212.5457.54goldencheetahGoldenCheetah3.5goldendictGoldenDict1.5.0-RC2goldenpassportGoldenPassport0.1.6gollyGolly4.0.1goneovimGoneovim0.4.13goodsyncGoodSync11.9.1goofyGoofy3.5.4google-ads-editorGoogle Ads Editorlatestgoogle-analytics-opt-outGoogle Analytics Opt Out1.0.1google-assistantGoogle Assistant Unofficial Desktop Client1.0.0google-chatChat20.11.241google-chat-electrongoogle-chat-electron2.12.1google-chromeGoogle Chrome96.0.4664.55google-cloud-sdkGoogle Cloud SDKlatestgoogle-driveGoogle Drive52.0.6google-drive-file-streamGoogle Pepakura Designer 4.2.4 Crack+ Keygen Code 2021 - Activators Patch File Stream44.0.14.1google-earth-proGoogle Earth Pro7.3.4.8248google-featured-photosGoogle Featured Photos1.0.0.208google-japanese-imeGoogle Japanese Input Method Editorlatestgoogle-trendsGoogle Trends Screensaverlatestgoogle-web-designerGoogle Web Designer9.0.7.0googleappengineGoogle App Engine1.9.89gopandaGoPanda2.7.8gopass-uiGopass UI0.8.0gosignGoSign Desktop1.1.7gotiengvietGoTiengViet2.2,30gotomeetingGoToMeeting19796gpg-suiteGPG Suite2021.2gpg-suite-no-mailGPG Suite (without GPG Mail)2021.2gpg-suite-pinentryGPG Suite Pinentry2021.2gpg-syncGPG Sync0.3.6gplatesGPlates2.2gpoddergPodder3.10.21gpowerG*Power3.1.9.6gps4camgps4cam7.2gpxseeGPXSee9.11gqrxGqrx2.14.6gradsGrid Analysis and Display System2.2.1grafxGrafX22.8.3104,67grammarlyGrammarly1.5.80grampsGramps5.1.4,5grandperspectiveGrandPerspective2.5.4grandtotalGrandTotal7.2graphicconverterGraphicConverter11.5.4,5261graphiqlGraphiQL App0.7.2graphql-ideGraphQL IDE1.1.1graphql-playgroundGraphQL Playground1.8.10graphsketcherGraphSketcher2.0_test_46grayGray0.17.0greenfootGreenfoot3.7.0gretlgretl2021dgridGrid1.4grid-clockGrid Clock Screensaver0.0.5grideaGridea0.9.2gridsGrids7.0.16grisbiGrisbi2.0.5growlnotifyGrowlNotify2.1gswitchgSwitch1.9.7gtkwaveGTKWave3.3.107guijsguijs0.1.19guild-wars2Guild Wars 21.0guildedGuilded1.0.9115342guitar-proGuitar Pro7.5gulpgulp-app0.1.0guppyGuppy0.3.0gureumkim구름 입력기1.11.1gyazmailGyazMail1.6.5gyazoNota Gyazo GIF3.9.0gzdoomGZDoom4.7.1ha-menuHA Menu2.5.1hacker-menuHacker Menu1.1.5hackintoolHackintool3.6.6hackmdHackMD0.1.0hakunekoHakuNeko6.1.7hammerspoonHammerspoon0.9.91hancockHancock1.2.1hancom-wordHacom Word Processor 2014 VPlatesthandbrakeHandBrake1.4.2handbrakebatchHandBrakeBatch2.25handshakerHandShaker2.5.6,408happygrephappygrep1.0happymacHappyMac0.1.0haptic-touch-barHaptic Touch Bar2.4.0,1540815050haptickeyHapticKey0.7.0harborHarbor0.1.2harmonyHarmony0.9.1haroopadHaroopad0.13.2harvestHarvest2.2,203hashbackuphashbackup2552hazelHazel5.1hazeoverHazeOver1.8.9,1050:10.13hbuilderxHBuilderX3.2.12.20211029hdrmergeHDRMerge0.5.0headsetHeadset3.3.3heavenHeaven Benchmark4.0hedgewarsHedgewars1.0.0heimdall-suiteHeimdall Suite1.4.0heliumHelium1.0heloHELO1.6.2hermesHermes1.3.1,2058hermit-crabHermit Crab1.0.3hex-fiendHex Fiend2.14.1heyHEY1.2.2hfsleuthHFSleuthlatesthiarcs-chess-explorer(Deep) HIARCS Chess Explorer1.11hiddenbarHidden Bar1.8hightopHighTop1.2.11historyhoundHistoryHound2.3.2,8864hma-pro-vpnHMA! Pro VPNlatesthocus-focusHocus Focus1.3,2131holavpnHola VPN2.38,1.190.307home-assistantHome Assistant2021.11.1,2021.266home-inventoryHome Inventory3.8.5,20201209honerHoner1.1hontohonto view app6.44.0,20200124hookHook3.3.1,2021.10hookshotHookshot1.23,53hopper-debugger-serverHopper Debugger Server2.7horndisHoRNDIS9.2horosHoros – Free, open medical image viewer4.0.0hoststoolHosts tool for Mac2.7.0hotHot1.6.1hotswitchHotSwitch1.21houdahspotHoudahSpot6.1.8,699housepartyHouseparty1.14.6,4707hp-eprintHP ePrint2.5.0hp-primeHP Prime2020_01_16hstrackerHearthstone Deck Tracker2.0.2http-toolkitHTTP Toolkit1.5.0hubstaffHubstaff1.6.2,3675hue-topiaHue-topia3.4.2,1813huginHugin2019.2.0hushHush1.0hwsensorsHWSensors6.26.1440hydrogenHydrogen1.1.0hydrus-networkhydrus-network461hypeTumult Hype4.1.7,736hyperHyper3.1.4hyperbackupexplorerHyperBackupExplorer3.0.0-0149hyperdockHyperDocklatesthyperkeyhyperkey0.11hyperswitchHyperSwitch0.2.592-devi1profileri1Profiler3.3.0.13512ibabeliBabel3.6ibackupiBackup7.6ibackup-vieweriBackup Viewer4.2360ibackupbotiBackupBot5.6.0ibetterchargeiBetterCharge1.0.12,1568119585ibm-aspera-connectIBM Aspera Connect3.11.2.63ibm-cloud-cliIBM Cloud CLI2.2.0iborediBored1.2.1icabiCab6.0.9icanhazshortcutiCanHazShortcut1.3.0iccInternational Chess Club1.0,7648icebergIceberg1.3.1icefloorIceFloor2.0.2icestudioicestudio0.7.0icloud-controliCloud Control1.2.0icollectionsiCollections6.8.3,68301iconizerIconizer2020.11.0iconjarIconJar2.9.0,49047iconsIcons1.1icons8Icons8 App5.7.4,57400iconscoutIconscout1.0.1iconsetIconset2.0.0icqICQ3.0.32393id3-editorID3 Editor1.28.50idafreeIDA Free7.6idagioIDAGIO1.1.2idefragiDefrag5.3.1idisplayiDisplaylatestidriveiDrivelatestieasemusicieaseMusic1.3.4iexploreriExplorer4.5.0,178ifunboxiFunBox1.8igdmIG:dm3.0.3igetteriGetter2.9.7iglanceiGlance2.1.0igvIntegrative Genomics Viewer (IGV)2.11.3iinaIINA1.2.0,129iina-plusIINA+0.5.22,21102812ilok-license-manageriLok License Manager5.4.1,3455ilspyILSpy7.0-rc2ilya-birman-typography-layoutIlya Birman Typography Layout3.7image-toolImage Tool1.4.1image2iconImage2Icon2.16,930imagealphaImageAlpha1.5.1imagejImageJ1.53imageminimagemin0.1.0imageoptimImageOptim1.8.8imazingiMazing2.14.5,15503imdoneimdone1.22.3imgotv芒果TV6.4.3immersedImmersed15.9,131imoImo Messanger1.2.1impactorImpactor0.9.55inav-configuratorINAV Configurator3.0.2inboardInboard1.1.5,431indigoIndigo Domotics7.4.1infinityInfinity1.0.0infoflowBaidu Hi2.3.9.5,2021103019informInform6M62informantInformant0.09.4infrainfra0.46.0inkdropInkdrop5.2.0inkscapeInkscape1.1.1inkyInky0.12.0inloop-qlplaygroundinloop-qlplayground1.0insoinso2.4.0insomniaInsomnia2021.6.0inssiderinSSIDer0.0.4.5,8install-disk-creatorInstall Disk Creator1.5instatus-outInstatus Out1.0.8insyncInsync3.6.0.50200integrityIntegrity10.4.5intel-haxmIntel HAXM7.7.0intel-power-gadgetIntel Power Gadget3.7.0,b7b1b3e1dffd9b20intel-psxe-ce-c-plus-plusIntel Parallel Studio XE Composer Edition for C++2020.2.899,16768intellidockIntelliDock1.0intellij-ideaIntelliJ IDEA Ultimate2021.2.3,212.5457.46intellij-idea-ceIntelliJ IDEA Community Edition2021.2.3,212.5457.46interarchyInterarchy10.0.7internxt-driveInternxt Drive1.4.1intune-company-portalCompany Portal2.12.210101invesaliusInVesalius3.1.99995invisiblixinvisibliX3.2invisionsyncInVision Sync1.9.1,692invisor-liteInvisor Lite3.17,989.211020invokerInvoker2.8.0ionic-labIonicLab0.29.1ioquake3ioquake31.36ios-app-signeriOS App Signer1.13.1ios-consoleiOS Console1.0.2,55ios-saveriOS 8 Lockscreen for OSXlatestiota-walletIOTA Wallet2.5.7ip-in-menu-barIP in menu bar4.6.1.0.44ipa-managerIPA Palette2.3.2,2020.01.26ipartitioniPartition3.6.2ipeIpe7.2.24ipepresenterIpePresenter7.2.24ipfsIPFS Desktop0.17.0iphoto-library-manageriPhoto Library Manager4.2.7,954ipremoteutilityFlanders IP Remote Utility1.8.7ipsecuritasIPSecuritas5.0.1ipvanish-vpnIPVanish3.3.0,67479ipynb-quicklookipynb-quicklook0.1.2irccloudIRCCloud Desktop0.16.0ireadfastiReadFast2.0iridiumIridium Browser2021.10.95irisIris1.2.0iriunwebcamIriun2.7.1irpf2021IRPF 20211.9isabelleIsabelle2021ishowuiShowU1.94.5,2751ishowu-instantiShowU Instant1.4.8,1383isimulatoriSimulator3.3.0islideiSlide1.2.0isolatorIsolator4.99betaistat-menusiStats Menus6.61istat-serveriStat Server3.03istegiSteg1.6.2istumbleriStumbler103.43isubtitleiSubtitle3.4.6,49iswiffiSwiff1.14,94isynceriSyncer3.8.0isyncriSyncr Desktop6.1.0itauItau2.1.2.18itchitch.io25.5.1iterm2iTerm23.4.12ithoughtsxiThoughtsX5.29.0itk-snapITK-SNAP3.8.0,20190612itoolsiTools2.9.2itrafficitraffic0.1.4itsycalItsycal0.13.1,2150itubedownloaderiTubeDownloader6.6.0,66000itunes-produceriTunes Producer3.1.2itunes-volume-controliTunes Volume Control1.6.8ivideonserverIvideon Client3.10.1ivolumeiVolume3.9.0,2260ivpnIVPN3.4.0izipiZip3.9jJ902jabrefJabRef5.3jadJad1.5.8gjaikozJaikoz10.1.2,1.0jalbumjAlbum23.1jalviewJalview2.11.1.4jameicaJameica2.10.0jamesJames2.1.2jamf-migratorJamfMigrator5.9.3jamiJami202111051146jamkazamJamKazam1.0.4048jamovijamovi2.2.2.0jamulusJamulus3.8.1jandiJANDI1.4.6,201106jandi-statusbarjandi1.8jaspJASP0.16.0.0jasperJasper1.0.5jaxx-libertyJaxx Blockchain Wallet2.6.5jazzupJazzUp1.0b3,3jbidwatcherJBidwatcher2.99pre5jbrowsejbrowse1.16.11jclasslib-bytecode-viewerjclasslib bytecode viewer6.0.1jcryptoolJCrypTool1.0.7jd-guiJD-GUI1.6.6jdiskreportJDiskReport1.4.1jdk-mission-controlJDK Mission Control8.1.0,07jdownloaderJDownloaderlatestjeditjEdit5.6.0jedit-omegaJedit Ω2.43jellybeansoup-netflixNetflix1.0.5jellyfinJellyfin10.7.7jellyfin-media-playerjellyfin-media-player1.6.1jenkins-menuJenkins Menu0.2.0jetCodeship Jet2.11.0jetbrains-spaceJetBrains Space2021.3.2jetbrains-toolboxJetBrains Toolbox1.22,1.22.10774jettisonJettison1.8.2,3340jewelryboxJewelryBox1.5jgraspjgrasp2.0.6_08jgrennison-openttdJGR's OpenTTD Patchpack0.44.0jietuJietu2.2.2,11054jigglerJiggler1.9jiohomeJioHome2.0.7jitouchjitouchlatestjitsiJitsi2.10.5550jitsi-meetJitsi Meet2021.11.2jmcjmc0.3-betajoinmejoin.me3.22.0.14903jokerJoker iOS kernelcache handling utilitylatestjollysfastvncJollysFastVNC1.58,1925902joplinJoplin2.5.12joshjon-nocturnalNocturnal1.1.1josmJOSM18303journeyJourney2.14.6jpadilla-rabbitmqRabbitMQ3.6.1-build.1jpadilla-redisRedis4.0.2-build.1jprofilerJProfiler12.0.4jqbxJQBX0.9.190jsuiJSUI0.0.25jtooljtoollatestjtool2jtool22020.02.10jublerJubler7.0.3juliaJulia1.6.3jumpJump Desktop8.8.16,80816jumpcutJumpcut0.75jumpshareJumpshare2.7.3,103jupyter-notebook-qlJupyter Notebook Quick Look0.2jupyter-notebook-viewerJupyter Notebook Viewer0.1.4jupyterlabJupyterLab App3.2.3-1kactusKactus0.3.34kakapoKakapo1.3.0kakuKaku2.0.2kaleidoscopeKaleidoscope3.1.2,2022kapKap3.4.2kapitainsky-rclone-browserRclone Browser1.8.0,a0b66c6kapowKapow1.5.10karabiner-elementsKarabiner Elements13.7.0katalon-studioKatalon Studio8.1.0katanaKatana1.4.4katrainKaTrain1.10.1kawaKawa1.1.0kdiff3KDiff31.9.3kdocs金山文档3.0.1,1001keepKeep1.2.0keep-itKeep It1.11.6,9180keepassxKeePassX2.0.3keepassxcKeePassXC2.6.6keeper-password-managerKeeper Password Manager16.3.2,202111122144keepingyouawakeKeepingYouAwake1.6.1keewebKeeWeb1.18.7kekaKeka1.2.18kekaexternalhelperKeka External Helper1.1.1,1.2.7kernKern1.1.5kext-updaterKext Updater3.9.7,397kext-utilityKext Utility2.6.6kextviewrKextViewr1.1.0key-codesKey Codes2.2.1,2027keybaseKeybase5.8.0,20210920184218:a.keyboard-cleanerKeyboard Cleaner1.2keyboard-lockKeyboard Lock1.0keyboard-maestroKeyboard Maestro10.0.1,1001keyboardcleantoolKeyboardCleanTool3keyboardholderKeyboardHolder1.3.2keycastKeyCast1.1keycastrKeyCastr0.9.11keycombinerkeycombiner0.5.0
Источник: https://formulae.brew.sh/cask/

PDF-XChange Viewer 2.5.322.10

Those Wishing To View PDF Files On Their Windows PC´s Now Have A Choice When It Comes To Viewing PDF Files - The PDF-XChange Viewer Is Smaller, Faster And More Feature Rich Than The Adobe Reader.

The FREE PDF-XChange Viewer Offers All The Feature´s You Would Expect Such As Support Of All PDF File Formats From Version 1.0 All The Way To The Latest.

You Might Be Surprised Just How Quickly Your Large PDF Files Open And Pages Smoothly Refresh As They Are Scrolled.

Features:

  • Tabbed Multiple Document Windows
  • Add Comments And Annotations To Any PDF File (subject To Security Settings) - Unlilke The Adobe Viewer Which Requires The PDF Creation Tool To Be ´certified´ By Adobe !
  • Markup Pages With Text And Objects
  • Type Directly On Any PDF Page, Not Just Adobe Enabled Forms Documents - In Typewriter Mode.
  • Export PDF Pages Or Entire Files To Any One Of The Supported Image Formats Including BMP, JPEG, TIFF, PNG And Many More .
  • Extract Text From A PDF Page/File
  • Make Your Navigation Of Large Or Complex PDF Files Both Simple And Enjoyable Swith The Extended Functionality Of Our ´Loupe´ And The ´Pan´ Window Tools
  • And Many More Features Such As Rotate And ´Save´, Email Files Etc
Источник: https://www.softerm.net/software/pdf-xchange-viewer-2532210/10342

Google Chrome version history

Major version Release date Layout engine[r 1]V8 engine[r 2]Significant changes Issues/Bugs 0.2.149 2008-09-02 WebKit 522 0.3 0.3.154 2008-10-29
  • Improved plugin performance and reliability
  • Spell checking for input fields
  • Improved web proxy performance and reliability
  • Tab and window management updates
0.4.154 2008-11-24 WebKit 525
  • Bookmark manager with import and export support
  • Privacy section added to the application options
  • New blocked popup notification
1.0.154 2008-12-11 WebKit 528 2.0.172 2009-05-24 WebKit 530 0.4
  • 35% faster JavaScript on the SunSpider benchmark
  • Mouse wheel support
  • Full-screen mode
  • Full-page zoom
  • Form auto-fill
  • Sort bookmarks by title
  • Tab docking to browser and desktop edges
  • Basic Greasemonkey support[r 4]
3.0.195 2009-10-12 WebKit 532 1.2
  • New "new tab" page for improved customization
  • 25% faster JavaScript
  • HTML5 video and audio tag support
  • Lightweight theme support[r 5]
4.0.249 2010-01-25 WebKit 532.5 1.3
  • Extensions
  • Bookmark synchronization
  • Enhanced developer tools
  • Improved HTML5 support
  • Performance improvements
  • Full Opera 55.0 Build - Crack Key For U pass
  • HTTP byte range support
  • Experimental new anti-reflected-XSS feature called "XSS Auditor"[r 6]
4.1.249 2010-03-17 5.0.375 2010-05-21 WebKit 533 2.1 6.0.472 2010-09-02 WebKit 534.3 2.2
  • Updated and more streamlined UI with simplified Omnibox
  • New tab page
  • Merged menu buttons
  • Form auto-fill
  • Expanded synchronization support to include extensions and auto-fill data
  • Support for WebM videos
  • Built-in PDF support (disabled by default)[r 11]
7.0.517 2010-10-21 WebKit 534.7 2.3.11
  • Implemented HTML5 parsing algorithm
  • File API
  • Directory upload via input tag
  • macOS version gained AppleScript support for UI automation[r 12]
  • Late binding enabled for SSL sockets: high priority SSL requests are now always sent to the server first.
  • New options for managing cookies
  • Updated New Tab page to enable featuring of web applications
8.0.552 2010-12-02 WebKit 534.10 2.4.9
  • Chrome Web Store
  • Built-in PDF viewer that works inside Chrome's sandbox for increased security
  • Expanded synchronization support to include web applications
  • Improved Opera 55.0 Build - Crack Key For U handling[r 13]
  • This release added "about:flags" to showcase experimental features such as Chrome Instant, side tabs on Windows, tabbed settings, Click to Play,[clarification needed] background web applications, Remoting,[clarification needed] disables outdated plug-ins,[clarification needed] XSS Auditor,[clarification needed] Cloud Print Proxy,[clarification needed] GPU-accelerated compositing, WebGL support for the canvas element, and a "tab overview" mode (like Exposé) for macOS.
9.0.597 2011-02-03 WebKit 534.13 2.5.9 10.0.648 2011-03-08 WebKit 534.16 3.0.12
  • Google Cloud Print sign-in interface enabled by default
  • Partially implemented sandboxing of the GPU process[r 16][r 17]
  • Faster JavaScript performance due to incorporation of Crankshaft, an improved compiler for V8[r 18]
  • Settings pages that open in a tab, rather than a dialog box
  • Malware reporting and disabling outdated plugins
  • Password sync
  • GPU accelerated video
  • Background WebApps
  • webNavigation extension API[r 19]
11.0.696 2011-04-27 WebKit 534.24 3.1.8 12.0.742 2011-06-07 WebKit 534.30 3.2.10
  • Hardware accelerated 3D CSS
  • New Safe Browsing protection against downloading malicious files
  • Ability to delete Flash cookies from inside Chrome[r 22]
  • Launch Apps by name from the Omnibox
  • Integrated Sync into new settings pages
  • Improved screen reader support
  • New warning when hitting Command-Q on Mac[r 22]
  • New flags: P2P API
  • Existing tab on foreground on open
  • Experimental new tab page
  • Add grouping to tab context menu
  • Run PPAPI Flash in the renderer process
  • Multiple profiles
  • Removed Google Gears
  • Print and Save buttons in the PDF viewer[r 23]
13.0.782 2011-08-02 WebKit 535.1 3.3.10
  • Instant Pages (pre-rendering of Web pages)[r 24]
  • Native print interface and preview (Linux and Windows only)
  • Experimental new tab page
  • Experimental Restrict Instant To Search option
14.0.835 2011-09-16 3.4.14
  • Native Client (NaCl) enabled for apps in the Chrome Web Store[r 25]
  • Web Audio API
  • Additional macOS Lion feature support
  • Sync Encryption for all data
  • Print preview on Mac
  • Validation of HTTPS sites[r 26]
  • Experimental Web Request extension API
  • Experimental Content Settings extension API[r 27]
15.0.874 2011-10-25 WebKit 535.2 3.5.10
  • Faster print preview[r 28]
  • Redesigned new tab page on by default[r 28]
  • JavaScript fullscreen API enabled by default[r 28]
  • Inline installation of Chrome Web Store items by verified sites
  • Omnibox History synchronization[r 29]
  • Switched to FFmpeg native VP8 decoder[r 30]
  • Extensions integrated into settings pages
  • GPU Accelerated Canvas 2D disabled
16.0.912 2011-12-13 WebKit 535.7 3.6.6
  • Multiple profiles on by default[r 29]
  • Optional how to use video solo - Free Activators in Chrome extensions, so the user can opt-in or opt-out of the optional permissions at installation time[r 31]
  • Experimental support for side tabs was removed.[r 32]
17.0.963 2012-02-08 WebKit 535.11 3.7.12 18.0.1025 2012-03-28
2012-06-27 (Android ARM)
2012-09-26
(18.0.1026, Android x86) WebKit 535.19 3.8.9 19.0.1084 2012-05-15
2012-06-28 (iOS) WebKit 536.5 3.9.24 20.0.1132 2012-06-26 WebKit 536.10 3.10.6
  • Experimental touch friendly user interface adjustments. Context menus have extra vertical padding between items.[r 42]
  • New tab button is bigger and wider
21.0.1180 2012-07-31
2012-08-22 (iOS) WebKit 537.1 3.11.10
  • Media Stream API (getUserMedia) enabled by default. (E.g. webcam access via JavaScript.)[r 43]
  • Gamepad API prototype available by default.
  • Support for (pointer) and (hover) CSS media queries so sites can optimize their user interface for touch when touch-screen support is available.
  • HTML5 audio/video and WebAudio now support 24-bit PCM wave files
    • Note: This is the last version of Chrome that will run on Mac OS X 10.5.8 Leopard. (undocumented)
22.0.1229 2012-09-25 WebKit 537.4 3.12.19 23.0.1271 2012-11-06
2012-11-28 (iOS) WebKit 537.11 3.13.7
  • Do Not Track preference[r 47]
  • Hardware video acceleration with 25% more efficient power consumption in some scenarios
  • Manager for site permission control
  • New icon for Chrome Web Store when opening new tab
  • PPAPI Flash Player (or Pepper-based Flash Player) replaced the NPAPI Flash Player on Mac also[r 48]
24.0.1312 2013-01-10 WebKit 537.17 3.14.5 25.0.1364 2013-02-21
2013-02-27 (Android)
2013-03-04 (iOS) WebKit 537.22 3.15.11

Android version (update from 18):

  • Newer V8 JavaScript engine
  • Audio now continues to play while Chrome is in the background
  • Support for pausing audio in Chrome when phone is in use
26.0.1410 2013-03-26
2013-04-03 (Android)
2013-04-09 (iOS) WebKit 537.31 3.16.14

Android version:[r 57]

  • Autofill and password sync
  • Performance and stability improvements
27.0.1453 2013-05-21
2013-05-22 (Android)
2013-06-03 (iOS) WebKit 537.36 3.17.6

Android version:[r 60]

  • Fullscreen on phones (scrolling down the page makes the toolbar disappear)
  • Simpler searching (the query stays visible in the omnibox, making it easier to edit)
  • Client-side certificate support
  • Tab history on tablets
  • "A ton of stability and performance fixes"
28.0.1500 2013-06-17 (Linux)
2013-07-09
(macOS and Windows)
2013-07-10 (Android)
2013-07-17 (iOS) Blink 28 (except iOS) 3.18.5

Android version:

iOS version:

29.0.1547 2013-08-20
(Linux, macOS, and Windows)
2013-08-21 (Android)
2013-09-12 (iOS) Blink 29 (except iOS) 3.19.18
  • Support for VP9 final
  • Support for Opera 55.0 Build - Crack Key For U 1.2
  • Preliminary QUIC support[r 68]
  • Improved Omnibox suggestions based on the recency of visited sites
  • Ability to reset user profile back to its original state
  • New apps and extensions APIs (such as Native Messaging API for connecting Chrome with native applications installed on the same computer - an alternative to NPAPI[r 69])

Android version:

  • WebRTC support[r 70]
  • WebAudio support[r 70]
  • Improved scrolling responsiveness[r 71] and visual indication when scrolling to the top or bottom of a page[r 70]
  • Startup performance and stability improvements[r 71]
  • New color picker user interface for web forms[r 70]
  • Support for Google's experimental data compression service (comparable to Opera Turbo) that lets Google servers quickly read and optimize a Web page for mobile devices, then transmit it to the smartphone using Google's SPDY network technology.
  • Rudimentary tab groups implemented

iOS version:

  • Get back to Search Results faster
  • Data cost savings enhancements (rolled out incrementally)
  • Voice search pronoun support (e.g. queries like: “Who is the president of the United States?” followed by “Who is his wife?”)
  • Improvements to Single Sign On with other Google Apps[r 72]
  • Support for WebP image format[r 73]
30.0.1599 2013-09-18 (iOS)
2013-10-01
(Linux, macOS, and Windows)
2013-10-02 (Android) Blink 30 (except iOS) 3.20.17
  • New image context menu item: "Search Google for this image"
  • New Chrome Apps APIs: webview.request, media gallery write support and downloads[r 74]
  • New platform features (both in desktop and mobile): support for the WebRTC Device Enumeration API, allowing users to change their microphones and/or camera on the fly without having to restart the WebRTC call, DevTools now supports CSS source maps, Chrome will now match the behavior of IE and not honor the Refresh header or tags when the URL to be refreshed to has a javascript: scheme[r 74]

Android version:

  • New gesture: swipe horizontally across the top toolbar to quickly switch tabs
  • New gesture: drag vertically down from the toolbar to enter into the tab switcher view
  • New gesture: drag down from the menu to open the menu and select wanted item without having to lift finger
  • WebGL is enabled by default on high-end devices[r 74]
  • DeviceMotion (device acceleration and rotation rates) events[r 74]
  • Media Source Extension is enabled on Android 4.1+[r 74]
  • Two new experimental features behind a flag: Web Speech API (recognition) and the Vibration API[r 74]

iOS version:

  • New look and feature enhancements for iOS7
  • Improvements to Fullscreen behavior especially on iPad (iOS7 only)
  • New Settings UI
  • Maps and email links launch the Google Maps and Gmail apps (if installed) automatically. You can change your preference in Settings
  • Stability / security improvements and bug fixes[r 75]
31.0.1650 2013-11-12
(Linux, macOS, and Windows)
2013-11-14 (Android)
2013-11-20 (iOS) Blink 31 (except iOS) 3.21.18
  • Payment requestAutocomplete() on Chrome for Android, Windows, Chrome OS
  • PNaCl on desktop versions of Chrome
  • New Chrome Apps APIs: With URL handlers for apps, Chrome App developers can now specify URLs to be handled by a Chrome App. For example, a document link on a website could open a document editor Chrome App. This gives users more seamless entry points into their favorite Chrome Apps.
  • Directory access for Apps allows Chrome Apps to access and write to user-approved folders. This feature can be used to share files between a Chrome App and a native app. For example, a Chrome App code editor could modify files managed by a native Git client.
  • SCTP for WebRTC Data Channel allows P2P data transfers between browsers to be either best effort, reliable, or semi reliable, opening up use cases such as gaming.
  • Alpha channel support for WebM video enables transparency masking (a.k.a. green screen effects) in WebM videos.
  • Speech recognition with the JavaScript Web Speech API is now supported on Chrome for Android.
  • window.devicePixelRatio now takes full-page zoom (but not pinch zoom) into account
  • Support for { alpha: false } in getContext('2d') lets you create an opaque canvas. This is similar to existing WebGL functionality and can improve the rendering performance of your app.
  • The Media Source API has been unprefixed and is now supported on Chrome for Android. It allows JavaScript to generate media streams for playback, addressing use cases like adaptive streaming and time shifting live streams.
  • 2D canvas now supports the "ellipse" method.
  • Support for several Mutation Events has been removed. Consider using MutationObserver instead.[r 76]

iOS version:

  • Fast form completion with Autofill
  • Long press on an image to search for related images
  • Stability / security improvements and bug fixes[r 75]
32.0.1700 2014-01-14
(Linux, macOS, and Windows)
2014-01-15 (Android)
2014-01-27 (iOS) Blink 32 (except iOS) 3.22.24
  • Tab indicators for sound, webcam and casting
  • A different look for Win8 Metro mode
  • Automatically blocking malware files
  • A number of new apps/extension APIs
  • Various under-the-hood changes for stability and performance

Android version:

  • Add web page shortcuts right to your home screen more easily from the menu
  • Reduce data usage in Chrome up to 50%. Visit Settings > Bandwidth management > Reduce data usage to enable.[r 77]

iOS version:

  • Translate
    • When you come across a page written in a language that you don't understand, just look for the translation bar. One tap and the page is quickly translated for you.
  • Reduce Data Usage
    • Reduce your data usage by up to 50%. Enable this feature and view your savings: Settings > Bandwidth > Reduce Data Usage.
  • New Tab Page update to make searching faster and easier
    • This feature is being rolled out and will be available to all users over time, beginning on iPhone.
33.0.1750 2014-02-18 (iOS)
2014-02-20
(Linux, macOS, and Windows)
2014-02-26 (Android) Blink 33 (except iOS) 3.23.17

Android version:

iOS version:

34.0.1847 2014-04-02 (Android)
2014-04-08
(Linux, macOS, and Windows)
2014-04-29 (iOS) Blink 34 (except iOS) 3.24.35
  • Responsive Images and Unprefixed Web Audio
  • Import supervised users onto new computers
  • A different look for Windows 8 Metro mode
  • A number of new apps/extension APIs
  • New scroll bar look
  • Ignores autocomplete="off" on password input fields

Android version:

  • Battery usage optimizations

iOS version:

  • Updated tour when you start Chrome for the first time
  • Support for autocomplete in the omnibox for right to left languages
35.0.1916 2014-05-20 (Android)
2014-05-20
(Linux, macOS, and Windows)
2014-05-28 (iOS) Blink 35 (except iOS) 3.25.28
  • More developer control over touch input
  • New JavaScript features
  • Unprefixed Shadow DOM v0
  • A number of new apps/extension APIs
  • Opus updated to version v1.1

Android version:

  • Undo Tab Close
  • Fullscreen video with Subtitles and HTML5 controls
  • Support for some multi-window devices

iOS version:

  • Added right-to-left support to the omnibox for Arabic and Hebrew
  • See mac volume booster search term in the omnibox, instead of the long search query URL
  • Easily refine your search queries and view more results on the search results page
  • Stability improvements and bug fixes[r 75]

Linux version:

  • Switched graphics interface backend from GTK+ to Aura
36.0.1985 2014-07-15 (iOS)
2014-07-16
(Linux, macOS, and Windows)
2014-07-16 (Android) Blink 36 (except iOS) 3.26.31
  • Rich Notifications Improvements
  • An Updated Incognito / Guest NTP design
  • The addition of a Browser crash recovery bubble
  • Multiple stability and performance improvements[r 80]

Android version:

  • Improved text rendering on non-mobile optimized sites
  • Doodles return to the new tab page[r 81]

iOS version:

  • Allows mobile sites that have added Cast support to work with your Cast-enabled device
  • Stability improvements and bug fixes[r 82]

Linux version:

37.0.2062 2014-08-26
(Linux, macOS, and Windows)
2014-09-03 (Android)
2014-09-22 (iOS)[citation needed]Blink 37 (except iOS) 3.27.34
  • DirectWrite support on Windows for improved font rendering
  • A number of new apps/extension APIs
  • Discarded "Archived History" file previously used to store browsing history for longer than 90 days.[2][3]
  • Multiple stability and performance improvements[r 83]
  • Removal of the showModalDialog API, breaking several enterprise web apps[r 84]

Android version:

Windows version:

38.0.2125 2014-10-07
(Linux, macOS, and Windows)
2014-10-07 (iOS)
2014-10-08 (Android) Blink 38 (except iOS) 3.28.71

Android version:

  • Support for Battery Status and Screen orientation APIs
  • Additional Material Design updates
  • Bug fixes and performance improvements[r 89]

iOS version:

  • Better support for iPhone 6 and 6+
  • Download and open files in Google Drive
  • Stability improvements and bug fixes
  • Security fix[r 90]
39.0.2171 2014-11-12 (Android)
2014-11-18
(Linux, macOS, and Windows)
2014-11-24 (iOS)[citation needed]Blink 39 (except iOS) 3.29.88
  • Removes SSL/TLS protocol version fallback to SSLv3
  • 64-bit support for Mac
  • A number of new apps/extension APIs
  • Under-the-hood changes for stability and performance[r 91]

Android version:

40.0.2214 2015-01-20 (iOS)
2015-01-21
(Linux, macOS, and Windows)
2015-01-21 (Android) Blink 40 (except iOS) 3.30.33
  • Disabled SSLv3 support by default
  • The minimum SSL/TLS version can now be set through about:flags
  • Updated info dialog for Chrome app on Windows and Linux
  • A new clock behind/ahead error message[r 94]

Android version:

  • Updated page info and content settings UI
  • Number of bug fixes and performance improvements[r 95]

iOS version:

  • New look with Material Design bringing bold graphics, fluid motion, and tactile surfaces
  • iOS 8 optimizations and support for bigger phones
  • Support handoff from Chrome to your default browser on macOS
  • Stability improvements and bug fixes[r 96]
41.0.2272 2015-03-03
(Linux, macOS, and Windows)
2015-03-11 (Android)
2015-03-16 (iOS) Blink 41 (except iOS) 4.1.0
  • A number of new apps/extension APIs
  • Many under the hood changes for stability and performance[r 97]
  • Aero interface is disabled in Windows Vista

Android version:

  • The ability to pull to reload at the top of most pages
  • A number of bug fixes and performance improvements[r 98]
42.0.2311 2015-04-14
(Linux, macOS, and Windows)
2015-04-15 (Android)
2015-04-16 (iOS) Blink 42 (except iOS) 4.2.77
  • Support for NPAPI plugins disabled by default
  • A number of new apps, extension and Web Platform APIs (including the Push API)
  • Many under the hood changes for stability and performance[r 99]
  • Add Bookmark is now redesigned.

Android version:

  • Getting the latest updates from sites with notifications
  • Adding your favorite sites to your homescreen is now even easier
  • Bug fixes and speedy performance improvements[r 100]
43.0.2357 2015-05-19
(Linux, macOS, and Windows)
2015-05-27 (Android)
2015-06-01 (iOS) Blink 43 (except iOS) 4.3.61

Android version:

44.0.2403 2015-07-21
(Linux, macOS, and Windows)
2015-07-22 (iOS)
2015-07-29 (Android) Blink 44 (except iOS) 4.4.63
  • A number of new apps/extension APIs
  • Change in the loading page circle on Chrome tabs
  • Many under the hood changes for stability and performance[r 105]

Android version:

iOS version:

  • Swipe to navigate: swipe right or left to navigate backwards and forwards
  • Support for accessing Physical Web content from the Today view
  • Stability improvements and bug fixes[r 107]
45.0.2454 2015-09-01
(Linux, macOS, and Windows)
2015-09-01 (Android)
2015-09-02 (iOS) Blink 45 (except iOS) 4.5.103
  • Support for NPAPI plugins permanently disabled
  • A number of fixes and improvements[r 108]

Android version:

  • A number of fixes for a whole bunch of performance/stability/other issues.[r 109]
46.0.2490 2015-10-13
(Linux, macOS, and Windows)
2015-10-14 (Android)
2015-10-22 (iOS) Blink 46 (except iOS) 4.6.85
  • Change in taskbar logo design
  • A number of fixes and improvements.[r 110]

Android version:

47.0.2526 2015-12-01 (iOS)
2015-12-01
(Linux, macOS, and Windows)
2015-12-02 (Android) Blink 47 (except iOS) 4.7.80
  • Change in appearance on closing tabs with red x's
  • New PDF viewer design
  • Security fixes[r 112]

Android version:

  • "More than a barge load of performance and stability fixes".[r 113]

iOS version:

  • Added support for more keyboard shortcuts. Bluetooth keyboards can open, close or change tabs or conduct a voice search.
  • Support for 3D touch on iPhone 6s/+. Force touch the Chrome icon to quickly open a new tab, a new incognito* tab, or conduct a voice search.[citation needed]
48.0.2564 2016-01-20
(Linux, macOS, and Windows)
2016-01-27 (iOS)
2016-01-27 (Android) Blink 48 (except iOS) 4.8.271
  • "Tab discarding" was enabled by default in chrome://flags[permanent dead link]
  • Window change in right-clicking an embedded web link
  • The key icon in "Save your password" turns black
  • "Clear browsing history" has been improved
  • A large number of fixes and improvements[r 114]

Android version:

  • Bug fixes and speedy performance improvements.

iOS version:

  • This version uses WKWebView, the latest rendering engine from Apple.
  • The crash rate was reduced by IObit Uninstaller Pro Crack 11.0.1.14 With Serial Key Download Free and JavaScript execution is now faster.
  • Redesigned icons on the New Tab page: easier access to more of your frequently-visited sites.
  • Spotlight integration: Drag down or right from the Home screen and search for your Chrome bookmarks.[citation needed]
49.0.2623 2016-03-02
(Linux, macOS, and Windows)
2016-03-09 (iOS)
2016-03-09 (Android) Blink 49 (except iOS) 4.9.385
  • Extension icons now appear near search tab.
  • Changes in bookmark bar appearances.
  • Change in Incognito mode window.
  • Change in scrollbar movement.
  • Changed Downloads page appearance/design.
  • A large number of fixes and improvements[r 115]
  • Removed Windows 8 Mode (Metro mode)
  • Removed support 32-bit Linux, Ubuntu Precise (12.04), and Debian 7 (wheezy).
  • Last version available for Windows XP and Vista, as well as Mac OS X 10.6, 10.7, and 10.8.

Android version:

  • "More than a barge full of performance and stability fixes."[r 116]

iOS version:

  • Bookmarks has a new look: Easily find your favorites!
  • Bug and stability fixes.
50.0.2661 2016-04-13
(Linux, macOS, and Windows)
2016-04-20 (iOS)
2016-04-26 (Android) Blink 50 (except iOS) 5.0.71
  • Windows XP, Vista, Mac OS X 10.6, 10.7, and 10.8 compatibility broken.
  • Auto-fill form letters are now highlighted in bold.
  • A number of fixes and improvements.[r 117]

Android version:

  • Bug fixes and speedy performance improvements.

iOS version:

51.0.2704 2016-05-25
(Linux, macOS, and Windows)
2016-06-01 (iOS)
2016-06-01 (Android) Blink 51 (except iOS) 5.1.281

Android version:

  • Brought tab switching back into Chrome (Android L+)[r 119]
  • Bug fixes and speedy performance improvements.

iOS version:

52.0.2743 2016-07-20
(Linux, macOS, and Windows)
2016-07-27 (iOS)
2016-07-27 (Android) Blink 52 (except iOS) 5.2.361
  • It is impossible to disable DirectWrite.
  • Bar on the bottom now shows darker text when hovering your mouse over the link.
  • "A number of fixes and improvements."[r 120]

Android version:

iOS version:

  • Accelerated Mobile Pages ("AMP") – news and articles from many of your favorite publishers will now load instantly.
  • Lightning bolt and "AMP" next to articles in the "Top Stories" section of search results indicate faster web page loading.
53.0.2785 2016-08-31
(Linux, macOS, and Windows)
2016-09-07 (iOS)
2016-09-07 (Android) Blink 53 (except iOS) 5.3.332
  • New browser's inside look, including a new bookmark
  • "A number of fixes and improvements."[r 122]
  • 'Simplify page' option removed from 'Save as PDF'.
  • Shadow DOM v1[4]

Android version:

iOS version:

  • Chrome's History has a new look and it's now easier to review, find, and delete your browsing history.
  • Voice Search has been updated with a fresh look. Voice Search can now answer contextual questions such as "How tall is the Eiffel Tower?" followed by "When was it built?"
54.0.2840 2016-10-12
(Linux, macOS, and Windows)
2016-10-19 (iOS)
2016-10-19 (Android) Blink 54 (except iOS) 5.4.500
  • "Other bookmarks" tab has changed appearance
  • The message "Right-click to play Adobe Flash Player" now appears while pages with Adobe Flash Player are loading.
  • "A number of fixes and improvements."[r 125]

Android version:

  • Bug fixes and speedy performance improvements
  • View article suggestions for you on the new tab page
  • Play media in the background for sites that support it
  • Update saved passwords when you change or reset your password[r 126]

iOS version:

  • No internet connection? Smile and tap the dinosaur
  • Fixed bookmark icons not displaying correctly
  • Fixed phone number detection issues in web pages
  • Stability improvements and bug fixes
55.0.2883 2016-12-01
(Linux, macOS, and Windows)
2016-12-05 (iOS)
2016-12-06 (Android) Blink 55 (except iOS) 5.5.372
  • The History page has changed and is no longer in "Settings"
  • Flash Player is now off by default for most sites
  • "A number of fixes and improvements."[r 127]
  • It is not possible to disable top level Material Design[r 128]

iOS version:

  • You can swipe down or right from the iOS Home screen to search. Searching for "voice" or "incognito" enables you to start Chrome in Voice Search mode or in a new Incognito Tab, respectively. The appearance of items in Spotlight Search will only work for devices that support Spotlight Actions.
  • The folder named "All Bookmarks" has been removed from the Bookmarks view. You can access all your other devices’ Bookmarks by clicking on the other folders.

Android version:

  • Bug fixes and speedy performance improvements
  • Easily download music, videos, and even full web pages for viewing offline
  • View and share your downloads within Chrome
  • See misspelled words highlighted in text fields
  • Improvements to contextual search UI[r 129]
56.0.2924 2017-01-25
(Linux, macOS, and Windows)
2017-02-01 (iOS)
2017-02-01 (Android) Blink 56 (except iOS) 5.6.326
  • HTML5 enabled by default
  • Adobe Flash Player is automatically blocked for most sites that require the plugin
  • Labeling of unsecured HTTP sites
  • "A number of fixes and improvements."[r 130]

iOS version:

  • Scan a QR code or barcode by using 3D Touch on the app logo or searching for "QR" in Spotlight.
  • We've redesigned the tab switcher layout on iPad to make it easier to access your open sites.

Android version:

  • Easily download music, videos, and even full web pages for viewing offline
  • View and share your downloads within Chrome
  • See misspelled words highlighted in text fields
  • Improvements to contextual search UI
  • Bug fixes and significant memory savings[r 131]
57.0.2987 2017-03-09
(Linux, macOS, and Windows)
2017-03-14 (iOS)
2017-03-16 (Android) Blink 57 (except iOS) 5.7.492

iOS version:

  • Chrome can add pages to your Reading List.
  • Find in Page now works correctly in iOS 10.3.

Android version:

  • Quickly use emails, addresses, and phone numbers in web pages by tapping on them
  • Easily access downloaded files and web pages from the new tab page
  • Long press article suggestions on the new tab page to download them
  • Bug fixes and performance improvements[r 134]
58.0.3029 2017-04-19
(Linux, macOS, and Windows)
2017-04-20 (Android)
2017-04-25 (iOS) Blink 58 (except iOS) 5.8.283

Android version:

  • Useful actions like “Find in page” available in apps that open web pages using Chrome
  • More frequently updated article suggestions on the New Tab page
  • Use recently visited search engines as your default search engine
  • See Physical Web suggestions, based on your surroundings, in the address bar
  • Bug fixes and performance improvements[r 136]

iOS version:

  • Stability improvements and bug fixes.
59.0.3071 2017-06-05
(Linux, macOS, and Windows)
2017-06-06 (iOS)
2017-06-06 (Android) Blink 59 (except iOS) 5.9.211

iOS version:

  • Fixed a user-reported issue that resulted in hangs and significant slowdowns when switching tabs.
  • Fixed a crash involving dialogs presented while switching tabs.
  • Stability improvements and bug fixes.

Android version:

  • View and manage in-progress downloads on the Downloads page
  • View and clear your browsing data more easily on the redesigned History page
  • Long-press a link to open it in a new Chrome tab (from Chrome Custom Tabs)
  • Bug fixes and performance improvements[r 139]
60.0.3112 2017-07-25
(Linux, macOS, and Windows)
2017-07-25 (iOS)
2017-07-31 (Android) Blink 60 (except iOS) 6.0.286
  • MacBook Pro Touch Bar support.
  • "A number of fixes and improvements."[r 140]

iOS version:

  • "Request Mobile Site" button can switch from a website's desktop version back to its mobile version

Android version:

  • Load pages faster and use less memory with an updated JavaScript engine
  • Bug fixes and performance improvements
  • Clear browsing data more easily[r 141]
61.0.3163 2017-09-05
(Linux, macOS, and Windows)
2017-09-05 (iOS)
2017-09-05 (Android) Blink 61 (except iOS) 6.1.534
  • Native support for JavaScript modules
  • "A number of fixes and improvements."[r 142]

iOS version:

  • Added a new button for scanning QR codes above the virtual keyboard

Android version:

  • Addition of Web Share API
  • Bug fixes and performance improvements
  • Translate pages with a more compact and intuitive toolbar
  • Pick images to post online with an improved image picker[r 143]
62.0.3202 2017-10-17
(Linux, macOS, and Windows)
2017-10-18 (iOS)
2017-10-19 (Android) Blink 62 (except iOS) 6.2.414
  • The "Save Your Password" icon gets a new appearance
  • "A number of fixes and improvements."[r 144]
  • Support for OpenType variable fonts
  • Network Information API updated to report users actual Internet speed, not just connection type, to websites
  • HTTP sites that request user data will now be flagged as "non-secure" (red) in the Chrome Omnibox[r 145]

iOS version:

  • Two new Today widgets are added by tapping the Edit button at the bottom of the iOS Search screen
  • Ability to drag a URL from another app and drop it into Chrome's omnibox or WinZip 25.0 Build 14245 Crack Activation Code Free tab strip, or from Chrome's content area to another app on iOS 11 iPads
  • The Payment Request API has been introduced

Android version:

  • Download files faster with accelerated downloads
  • View and copy passwords saved with Chrome if device lock is enabled
  • Quickly see your data savings in the Chrome menu when Data Saver is on[r 146]
63.0.3239 2017-12-05 (iOS)
2017-12-05 (Android)
2017-12-06
(Linux, macOS, and Windows) Blink 63 (except iOS) 6.3.292
  • Various fixes from internal audits, fuzzing and other initiatives
  • "A number of fixes and improvements."[r 147]
  • Browser allows you to import JavaScript modules dynamically
  • With async generator functions and the async iteration protocol, consumption or implementation of streaming data sources becomes streamlined
  • You can override the browser's default overflow scroll behavior with microsoft office download - Crack Key For U CSS overscroll-behavior property[r 148]

iOS version:

  • Swipe up on the New Tab Page to explore suggested content from the web
  • The ability to reorder bookmarks is back!

Android version:

  • Chrome for Android will make permission requests modal dialogs
  • "Stability and performance improvements."[r 149]
64.0.3282 2018-01-23 (Android)
2018-01-24 (iOS)
2018-01-24
(Linux, macOS, and Windows) Blink 64 (except iOS) 6.4.388
  • "A number of fixes and improvements."[r 150]
  • Audio playback rates of below 0.5 and above 4.0 supported due to new, high-quality algorithm for stretching audio: "WSOLA" (Waveform-Similarity-Overlap-Add)[6]
  • Android: "share" menu picks pages' canonical URL instead of full URL from address bar.[7]
  • Support for ResizeObservers, will notify you when an element's content rectangle has changed its size.
  • Modules can now access to host specific metadata with import.meta.
  • The pop-up blocker gets stronger.
  • window.alert() no longer changes tab focus.
  • Chrome now supports named captures in avant browser bookmark location - Crack Key For U expressions.
  • The default preload value for <audio> and <video> elements is now metadata.
  • You can now use Request.prototype.cache to view the cache mode of a Request and determine whether a request is a reload request.
  • Using the Focus Management API, you can now focus an element without scrolling to it with the preventScroll attribute.[r 151]
  • Extensions page generates packages in CRX3 format now.[r 152]

Android version:

  • Prevents sites with abusive ad experiences from opening new windows or tabs without your permission.
  • "Stability and performance improvements."[r 153]

iOS version:

  • You can now disable Article Suggestions without also disabling omnibox suggestions by going to Chrome Settings
  • If you previously turned off "Search and Site Suggestions" to disable Article Suggestions and would like to turn back on winzip crack mac - Activators Patch Search Suggestions in the omnibox, you can do that from Chrome Settings > Privacy
  • Support for iPhone X
  • Now requires iOS 10 or later
65.0.3325 2018-03-06
(Linux, macOS, and Windows)
2018-03-06 (iOS)
2018-03-06 (Android) Blink 65 (except iOS) 6.5.254
  • "A number of fixes and improvements."[r 154]
  • New extension UI
  • The CSS Paint API allows you to programmatically generate an image
  • The Server Timing API allows web servers to provide performance timing information via HTTP headers
  • The new Opera 55.0 Build - Crack Key For U display: contents property can make boxes disappear
  • Fixed a bug that affected some timestamps
  • The syntax for specifying HSL and HSLA, and RGB and RGBA coordinates for the color property now match the CSS Color 4 spec
  • There's a new feature policy that allows you to control synchronous XHRs through an HTTP header or the iframe allow attribute[r 155]
  • Last version available for OS X 10.9.

Android version:

  • Set language preferences for web content in Settings > Languages
  • Turn on the prompt for simplified view for all supported articles in Settings > Accessibility settings
  • Share and delete downloads more easily on the Downloads page[r 156]
  • Disable screen capture on incognito mode [8]

iOS version:

  • Fixed a bug that affected some streaming audio players
  • Stability and performance improvements
66.0.3359 2018-04-17
(Linux, macOS, and Windows)
2018-04-17 (iOS)
2018-04-17 (Android) Blink 66 (except iOS) 6.6.346
  • "A number of fixes and improvements."[r 157]
  • CSS manipulation becomes easier with the new CSS Typed Model Object
  • Access to the clipboard is now asynchronous
  • There's a new rendering context for canvas EZ CD Audio Converter Crack 9.3.1.1 + Keygen 2021 and Select now support the autocomplete attribute
  • Setting autocapitalize on a form element will apply to any child form fields, improving compatibility with Safari's implementation of autocapitalize
  • trimStart() and trimEnd() are now available as the standards-based way of trimming whitespace from strings[r 158]

Android version:

  • Find your saved passwords more easily – just tap the new Search icon in Settings > Passwords[r 159]

iOS version:

  • Export passwords saved in Chrome and use them in another app
  • Stability and performance improvements
67.0.3396 2018-05-29
(Linux, macOS, and Windows)
2018-05-29 (iOS)
2018-05-31 (Android) Blink 67 (except iOS) 6.7.288
  • "A number of fixes and improvements."[r 160]
  • Progressive Web Apps are coming to the desktop
  • The generic sensor API makes it way easier to get access to device sensors like the accelerometer, gyroscope and more
  • BigInt's make dealing with big integers way easier.
  • Credential Management API provides a framework for creating, retrieving and storing credentials
  • The Web Authentication API adds a third credential type, PublicKeyCredential, which allows browsers to authenticate a user with a private/public key pair generated by an authenticator[r 161]

Android version:

iOS version:

  • Improved handling of boarding passes, movie tickets, etc. in Wallet
  • Updated app selection UI when you tap on an email link
  • Improved support for external keyboards
  • Improved issue reporting: now you can draw on screenshots you are sending with feedback reports to obscure private data
  • A fix has been provided for autofill issue (June 13)
68.0.3440 2018-07-24 (iOS)
2018-07-24
(Linux, macOS, and Windows)
2018-07-24 (Android) Blink 68 (except iOS) 6.8.275
  • "A number of fixes and improvements."
  • HTTP sites marked as "not secure".[r 163]
  • The Page Lifecycle API tells you when your tab has been suspended or restored.
  • The Payment Handler API makes it possible for web-based payment apps to support the Payment Request experience.
  • Content embedded in an iframe requires a user gesture to navigate the top-level browsing context to a different origin.
  • Since Chrome 1, the CSS cursor values for grab and grabbing have been prefixed; standard, un-prefixed values now supported.[r 164]

Android version:

  • Fix for an Autofill issue.[r 165]
  • The Add to Home Screen behavior on Android is changing to give you more control.

iOS version:

  • Improved downloading from websites. Downloading now works while the app is in the background. You can also continue browsing in the same tab while your file downloads.
  • Improvements to Forms Autofill.
  • Improved handling of links to the App Store.
69.0.3497 2018-09-04
(Linux, macOS, and Windows)
2018-09-04 (iOS)
2018-09-04 (Android) Blink 69 (except iOS) 6.9.427
  • "A number of fixes and improvements."[r 166]
  • New browser interface
  • CSS Scroll Snap allows you to create smooth, slick, scroll experiences.
  • Display Cutouts lets you use the full area of the screen, including any space behind the display cutout, sometimes called a notch.
  • The Web Locks API allows you to asynchronously acquire a lock, hold it while work is performed, then release it.
  • You can now create color transitions around the circumference of a circle, using conic gradients.
  • New toggleAttribute() method on elements toggles the existence of an attribute, similar to classList.toggle().
  • JavaScript arrays are getting two new methods: flat() and flatMap().
  • OffscreenCanvas moves work off the main thread in a worker, helping to eliminate performance bottlenecks.[r 167]

Android version:

  • Secure and easy mobile payments via 3rd party payment apps
  • Password generation now works on more sites[r 168]

iOS version:

  • New bottom toolbar: easier to reach frequently used functions, like Back, Search, tabs, and the menu
  • New tab grid: see bigger previews of your tabs, including tabs open on other devices
  • Features like Bookmarks and Reading Lists are now easily accessible on the New Tab Page
  • Press firmly on the app icon to see shortcuts (3D Touch)
  • Credit cards you enter on your device are now securely synced to Google Pay for use on other devices (if enabled)
70.0.3538 2018-10-16
(Linux, macOS, and Windows)
2018-10-16 (iOS)
2018-10-17 (Android) Blink 70 (except iOS) 7.0.276
  • "A number of fixes and improvements."[r 169]
  • Desktop Progressive Web Apps on Windows
  • The credential management API adds support for Public Key Credentials
  • Named workers
  • Web Bluetooth is now available in Windows 10
  • Chrome can send intervention and deprecation messages to your servers using the Report-To HTTP Response header field or surface them in the ReportingObserver interface
  • Support for AV1 video decoder (“Main” profile 0)[r 170]
  • A number of important deprecations[r 171]

Android version

  • "Stability and performance improvements"[r 172]
  • Cleaner, more modern design

iOS version:

71.0.3578 2018-12-04
(Linux, macOS, and Windows)
2018-12-04 (iOS)
2018-12-04 (Android) Blink 71 (except iOS) 7.1.302
  • "A number of fixes and improvements."[r 173]
  • Displaying relative times is now part of the Intl API
  • Specifying which side of the text the underline should appear on for text that flows vertically
  • Requiring user activation before using the speech synthesis API
  • The default credentials mode for module script requests has changed from omit to same-origin
  • Shadow DOM v1 spec; calculation for specificity for the :host() and :host-context() pseudo classes as well as for the arguments for ::slotted()[r 174]
  • Removed SpeechSynthesis.speak() without user activation
  • Removed prefixed versions of APIs
  • Removed URL.createObjectURL from MediaStream
  • Removed document.origin
  • Deprecations and removals of APIs[r 175]

Android version:

  • The Element.requestFullscreen() method can now be customized
  • "Stability and performance improvements."[r 176]

iOS version:

  • You can now long-press on an image and save to clipboard and paste in other apps
  • Autofill now works better on sites with iframes (embedded pages)
72.0.3626 2019-01-29
(Linux, macOS, and Windows)
2019-01-29 (iOS)
2019-01-29 (Android) Blink 72 (except iOS) 7.2.502
  • "A number of fixes and improvements."[r 177]
  • Creating public class fields in JavaScript is now much cleaner
  • New User Activation API
  • Localizing lists becomes way easier with the Intl.format() API
  • Chrome 72 changes the behavior of Cache.addAll() to better match the spec
  • Requests for favicons are now handled by the service worker, as long as the request URL is on the same origin as the service worker[r 178]
  • Pages may no longer use window.open() to open a new page during unload
  • Removal of HTTP-Based Public Key Pinning
  • Removal of rendering FTP resources
  • Deprecation of TLS 1.0 and TLS 1.1
  • Deprecation of PaymentAddress.languageCode[r 179]

Android version:

iOS version:

  • Support for more search engines
  • Fixed crashes on some page translations and added translations on previously untranslated websites
  • A Siri Shortcut to start a new search is available
73.0.3683 2019-03-12
(Linux, macOS, and Windows)
2019-03-12 (iOS)
2019-03-12 (Android) Blink 73 (except iOS) 7.3.492
  • "A number of fixes and improvements."[r 181]
  • Creating portable content is easier with signed HTTP exchanges
  • Dynamically changing styles becomes way easier with constructable style sheets
  • Support for Progressive Web Apps arrives on macOS, bringing support for PWAs to all desktop and mobile platforms
  • matchAll() is a new regular expression matching method on the string prototype, and returns an array containing the complete matches
  • The <link> element now supports imagesrcset and imagesizes properties to correspond to srcset and sizes attributes of HTMLImageElement
  • Blink's shadow blur radius implementation now matches Firefox and Safari
  • Dark mode is now supported on Mac, and Windows support is on the way[r 182]
  • Removal of EXPLAIN and REINDEX support in WebSQL
  • Removal of isomorphic decoding of URL fragment identifier
  • Deprecation of 'drive-by downloads' in sandboxed iframes[r 183]
  • Stoppage of support for external web extensions in CRX2 format, making CRX3 format required[r 184]

Android version:

  • Offline Content on the Dino Page: easily browse suggested articles while offline
  • Lite pages: get optimized pages that save data and load faster[r 185]

iOS version:

  • Tap on the icons above the keyboard and easily access your saved passwords, addresses and credit card information
  • Updated default search engines list
  • View JavaScript console messages
74.0.3729 2019-04-23
(Linux, macOS, and Windows)
2019-04-24 (Android)
2019-04-29 (iOS) Blink 74 (except iOS) 7.4.288
  • "A number of fixes and improvements."[r 186]
  • Creating private class fields in JavaScript is now much cleaner
  • You can detect when the user has requested a reduced motion experience
  • CSS transition events
  • Adds new feature policy APIs to check if features are enabled or not[r 187]
  • Removal of PaymentAddress's languageCode property
  • No popups during page unload
  • Deprecation of drive-by downloads in sandboxed iframes[r 188]

Android version:

  • Translate any web page instantly by selecting Translate from the menu[r 189]

iOS version:

  • You can now paste pictures from your clipboard into the omnibox to search
  • A fix has been included for translation not being offered on some English pages.
75.0.3770 2019-06-04
(Linux, macOS, and Windows)
2019-06-04 (iOS)
2019-06-04 (Android) Blink 75 (except iOS) 7.5.288
  • "A number of fixes and improvements."[r 190]
  • A new way to reduce latency on canvas elements
  • Web apps can now share files to other installed apps using the system level share sheet
  • Numeric literals now allow underscores as separators to make them more readable[r 191]
  • Removal of overflow: -webkit-paged-x and overflow: -webkit-paged-y[r 192]

Android version:

  • Generate strong and unique passwords with Chrome's built-in password manager
  • Quickly look up your passwords by tapping any password field and using the new keyboard option[r 193]

iOS version:

  • Links that are clicked in Incognito mode will no longer open native applications
  • Custom search engine settings now show the search engine's icon
76.0.3809 2019-07-30
(Linux, macOS, and Windows)
2019-07-30 (iOS)
2019-07-30 (Android) Blink 76 (except iOS) 7.6.303
  • "A number of fixes and improvements."[r 194]
  • Support for prefers-color-scheme media query, bringing dark mode to websites
  • An install button in the omnibox to make installation of Progressive Web Apps on desktop easier
  • Addition of Promise.allSettled()
  • Reading blobs is easier
  • Image support in the async clipboard API[r 195]
  • Removal of feature policy: lazyload
  • Removal of outputs from MediaStreamAudioDestinationNode
  • Removal of insecure usage of DeviceMotionEvent
  • Removal of insecure usage of DeviceOrientationEvent[r 196]

Android version:

  • "Stability and performance improvements."[r 197]
  • Preventing the mini-infobar from appearing on Progressive Web Apps on mobile
  • More frequent updates of WebAPKs

iOS version:

  • Find In Page now works on iFrames, including AMP (Accelerated Mobile Pages)
  • A suggestion for a strong and unique password on a keyboard when signing up to a new site
  • Control of all Sync and Google services settings in one place
  • Some users will see a new design for the way Chrome offers to save passwords
77.0.3865 2019-09-10
(Linux, macOS, and Windows)
2019-09-10 (iOS)
2019-09-10 (Android) Blink 77 (except iOS) 7.7.299
  • A number of fixes and improvements."[r 198]
  • Forms get some new capabilities
    • The formdata event
    • Form-associated custom elements
  • Native lazy loading
  • Chrome DevSummit 2019 is happening November 11–12, 2019
  • Introduction of Content Picker API
  • New measurement units in the intl.NumberFormat API[r 199]
  • Removal of card issuer networks as payment method names
  • Deprecation of Web MIDI use on insecure origins
  • Deprecation of WebVR 1.1 API[r 200]

Android version:

  • "Stability and performance improvements."[r 201]
  • A better way to track the performance of your site with Largest Contentful Paint

iOS version:

  • A new language settings page
  • You can clear your browsing data from a specific range of time
  • Omnibox suggestions are easier to read with added thumbnails and icons
  • Easily close tabs that are maliciously showing JavaScript dialogues
78.0.3904 2019-10-22 (iOS)
2019-10-22 (Android)
2019-10-22
(Linux, macOS, and Windows) Blink 78 (except iOS) 7.8.279

Android version:

  • "Stability and performance improvements."[r 205]
  • Dark theme for Chrome menus, settings, and surfaces

iOS version:

  • The ability to switch Chrome to dark mode if your device has been upgraded to iOS 13
  • Bookmarks, History, Recent Tabs, and Reading List are now presented as cards on iOS 13
  • The ability to add a new credit card directly in Chrome from the settings page
  • A fix for a navigation-related crash
79.0.3945 2019-12-10 (iOS)
2019-12-10
(Linux, macOS, and Windows)
2019-12-10 (Android) Blink 79 (except iOS) 7.9.317
  • "A number of fixes and improvements."[r 206]
  • The ability to create immersive experiences with the WebXR Device API
  • The Wake Lock API is available as an origin trial
  • The rendersubtree attribute is available as an origin trial
  • Videos from the Chrome DevSummit are now online[r 207]
  • Changes -webkit-appearance keywords to work only with specific element types[r 208]

Android version:

  • "Stability and performance improvements."
  • Password safety
  • Support for virtual reality
  • The ability to reorder bookmarks[r 209]
  • Installed Progressive Web Apps on Android now support maskable icons

iOS version:

  • Chrome will check if username and password are leaked if signed in to Chrome and then in to a website
  • Starting a search in the address bar will initiate top suggestions even if network connection is slow
80.0.3987 2020-02-04
(Linux, macOS, and Windows)
2020-02-04 (Android)
2020-02-05 (iOS) Blink 80 (except iOS) 8.0.426
  • "A number of fixes and improvements."[r 210]
  • Modules in workers
  • Optional chaining in JavaScript
  • New origin trials
  • Origin trial graduations
  • Using #:~:text=something will have Chrome scroll to and highlight the first instance of that text fragment
  • Setting display: minimal-ui on a Desktop PWA adds a back and reload button to the title bar of the installed PWA
  • Support for using SVG images as favicons[r 211]
  • Disallowed Synchronous XMLHTTPRequest() in Page Dismissal
  • Deprecation of FTP support
  • Removal of allowing popups during page reload
  • Non-origin-clean ImageBitmap serialization and transferring removed
  • Protocol handling now requires a secure context
  • Web Components v0 removed
  • Removal of -webkit-appearance:button for arbitrary elements[r 212]

Android version:

  • "Stability and performance improvements."
  • Quieter notifications
  • SameSite cookies are enabled by default
  • Insecure audio and video on secure pages are automatically upgraded to secure connections[r 213]

iOS version:

  • Starting a search in the address bar brings up top suggestions served locally even in Incognito Mode
81.0.4044 2020-04-07
(Linux, macOS, and Windows)
2020-04-07 (Android)
2020-04-07 (iOS) Blink 81 (except iOS) 8.1.307
  • "A number of fixes and improvements."[r 214]
  • Updated Chrome release schedule
  • WebXR hit testing
  • App icon badging
  • New origin trial of Web NFC and other origin trials
  • The media session API now supports tracking position state
  • INTL API now provides a DisplayNames method[r 215]
  • Deprecation and removal of "basic-card" support Payment Handler
  • Removal of supportedType field from BasicCardRequest
  • Removal of <discard> element
  • TLS 1.3 downgrade hardening bypass (Removal of TLS 1.0 and 1.1 is delayed to Chrome 84 due to the COVID-19 pandemic.)[r 216]

Android version:

  • "Stability and performance improvements."
  • 27 languages were added, including Burmese, Armenian, Urdu, Central Khmer, and Punjabi
  • Notification of whether a password is typed and saved on an unsafe site[r 217]

iOS version:

  • Updated Terms of Service
  • Finding downloads in the downloads folder in Chrome's menu or in the device's Files app
  • Search suggestions will also include suggestions from the middle of words
  • Fixes for crashes related to bookmarks and security
83.0.4103 2020-05-19
(Linux, macOS, and Windows)
2020-05-19 (Android)
2020-05-21 (iOS) Blink 83 (except iOS) 8.3.110
  • Version 82 was skipped due to the COVID-19 pandemic.
  • "A number of fixes and improvements."[r 218]
  • Trusted types help prevent cross site scripting vulnerabilities
  • Form elements get an important make-over
  • A new way to detect memory leaks
  • The native file system API starts a new origin trial with added functionality
  • New cross-origin policies
  • The Web Vitals program provides unified guidance for quality signals that are essential to delivering a great user experience on the web
  • Chrome now supports the Barcode Detection API, which provides the ability to detect and decode barcodes
  • The new CSS @supports function provides feature detection for CSS selectors
  • New ARIA annotations support screen reader accessibility for comments, suggestions, and text highlights with semantic meanings (similar to <mark>)
  • The prefers-color-scheme media query lets authors support their own dark theme so they have full control over experiences they build
  • JavaScript now supports modules in shared workers[r 219]
  • Disallowing of downloads in Sandboxed iframes[r 220]

Android version:

iOS version:

  • Allows users to see their last 5 search queries by tapping the address bar in a new tab when signed in with a Google account
  • Prompts and messages from Chrome have a refreshed look
  • iPhone users can change webpage text to a comfortable size by opening Chrome's menu and tapping "Zoom Text." or by going to their Accessibility settings
  • Updated Terms of Service.
84.0.4147 2020-07-14
(Linux, macOS, and Windows)
2020-07-14 (iOS)
2020-07-14 (Android) Blink 84 (except iOS) 8.4.371
  • "A number of fixes and improvements."[r 223]
  • App Icon Shortcuts
  • The Web Animations API adds support for a slew of previously unsupported features
  • Wake lock can prevent the screen from dimming or locking
  • The Content Indexing API helps surface content that is available offline
  • New origin trials for idle detection and Web Assembly SIMD
  • Same Site Cookie policy changes are starting to roll out again
  • Sites with abusive permission requests, or abusive notifications, will automatically be enrolled in our quieter notifications UI
  • New origin trial for QuicTransport[r 224]
  • @import rules in CSSStyleSheet.replace() removed
  • Removal of TLS 1.0 and TLS 1.1[r 225]

Android version:

iOS version:

  • New Safe Browsing features
  • Better mouse and trackpad support
  • You can now share a web page by creating and sharing a QR code
  • You can find your downloads in the downloads folder in Chrome's menu, or in your device's Files app
  • Addition of nicknames to your payment cards saved in Chrome[r 227]
Windows: 85.0.4183 2020-08-25
(Linux, macOS, and Windows)
2020-08-25 (iOS)
2020-08-25 (Android) Blink 85 (except iOS) 8.5.210
  • "A number of fixes and improvements."[r 228]
  • AppCache Removal Begins
  • Rejection of insecure SameSite=None cookies
  • -webkit-box quirks from -webkit-line-clamp[r 229]

iOS version:

  • Ability to use passwords saved to Chrome in other apps on the device
  • Site information has a new look
  • Users can drag links between the apps when another app is open next to Chrome in split view[r 230]
  • Fixes for clipboard crash and stability improvements

Android version:

86.0.4240 2020-09-30 (iOS)
2020-10-06 (Android)
2020-10-06
(Linux, macOS, and Windows) Blink 86 (except iOS) 8.6.395
  • "A number of fixes and improvements."[r 232]
  • The File System Access API is now available
  • New origin trials for Web HID and the Multi-screen Window DaVinci Resolve Studio Crack API
  • The new CSS selector, :focus-visible, lets the user opt-in to the same heuristic the browser uses when it's deciding whether to display the default focus indicator
  • The user can customize the color, size, or type of number or bullet for lists with the CSS ::marker Pseudo-Element[r 233]
  • Removal of WebComponents v0
  • Deprecation of FTP support[r 234]

Android version:

iOS version:

  • Ability to make Chrome the default browser
  • Ability to check if saved passwords have been compromised and, if so, how to fix them
  • More sharing, opening, and other options when user taps and holds Bookmarks, history, recent tabs, and read later
  • Improvements to the personalized stories on New tab page
  • Chrome will offer some additional protection by checking known phishing websites with Google in real time if "Make searches and browsing better" is turned on.
87.0.4280 2020-11-17
(Linux, macOS, and Windows)
2020-11-17 (Android)
2020-11-18 (iOS) Blink 87 (except iOS) 8.7.220
  • Automatic live captions for English video and audio.[11][12]
  • "A number of fixes and improvements."[r 236]
  • Users can now control pan, tilt, and zoom on webcams that support it
  • Range requests and service workers don't require as many workarounds
  • The font access API starts its origin trial
  • Flash Player end of support notifications now displaying at every launch unless Flash is disabled.
  • Transferable Streams - ReadableStream, WritableStream, and TransformStream objects can now be passed as arguments to postMessage()
  • Implemented most granular flow-relative features of the CSS Logical Properties and Values spec, including shorthands and offsets to make these logical properties and values a bit easier to gridinsoft trial @font-face descriptors have been added to ascent-override, descent-override, and line-gap-override to override metrics of the font
  • Several new text-decoration and underline properties
  • A number of changes related to cross-origin isolation[r 237]
  • Removal of comma separator in iframe allow attribute
  • Removal of -webkit-font-size-delta
  • Deprecation of FTP support[r 238]
  • Altered macOS icon to match the design style of MacOS Big Sur

Android version:

iOS version

  • Users can now have multiple windows of Chrome at the same time on their iPad
  • New feature in Settings: Safety Check
  • Auto-fill is now more secure[r 240]
88.0.4324 2021-01-19
(Linux, macOS, and Windows)
2021-01-19 (Android) Blink 88 (except iOS) 8.8.278
  • "A number of fixes and improvements."[r 241]
  • Users can now upload extensions using manifest v3 to the Chrome Web Store
  • CSS aspect-ratio property
  • Heavy throttling of chained JavaScript timers
  • Play billing in Trusted Web Activity
  • To conform to a change in the HTML standard, anchor tags with target="_blank" will now imply rel="no-opener" by default
  • Pointer Lock API allows users to disable mouse acceleration
  • addEventListener now takes an Abort Signal as an option[r 242]
  • No popups during page unload (enterprises)
  • Web Components v0 removed
  • Dropped support for OS X Yosemite
  • FTP support Adobe Fresco Crack 243]

Android version:

iOS version:

89.0.4389 2021-03-02
(Linux, macOS, and Windows)
2021-03-02 (Android) Blink 89 (except iOS) 8.9.255
  • "A number of fixes and improvements."[r 247]
  • WebHID, WebNFC, and Web Serial are now available
  • Closed a loophole a few developers used to skirt the PWA installability checks
  • The arrival of Web Share and Web Share Target
  • Chrome now allows top level await within JavaScript modules
  • Updated icon shown in the omnibox for installable PWAs
  • Allowed users to sign up for the Digital Goods API origin trial if they have used a Trusted Web Activity to make their PWA available in the Play Store for Chrome OS[r 248]
  • Removal of legacy prefixed events (webkitprerenderstart, webkitprerenderstop, webkitprerenderload, and webkitprerenderdomcontentloaded) dispatched on <link rel=prerender>
  • Stopped cloning sessionStorage for windows opened with noopener number[r 249]
  • Dropped support for older x86 processors that don't support SSE3[r 250]

Android version:

iOS version:

90.0.4430 2021-04-13 (Android)
2021-04-14
(Linux, macOS, and Windows)
2021-05-10 (iOS) Blink 90 (except iOS) 9.0.257
  • "A number of fixes and improvements."[r 252]
  • A new value for the CSS overflow property
  • The Feature Policy API has been renamed to Permissions Policy
  • A new way to implement and use Shadow DOM directly in HTML
  • Chrome's address bar will use https:// by default
  • AV1 encoder in desktop that is specifically optimized for video conferencing with WebRTC integration[r 253]
  • Removal of Content Security Policy directive 'plugin-types'
  • Removal of WebRTC RTP data channels
  • Return of empty for navigator.plugins and navigator.mimeTypes[r 254]

Android version

iOS version

  • Search and Dino widgets available on iOS 14
  • Users can edit saved usernames and passwords in Chrome Settings
  • Stability and performance improvements.[r 256]
91.0.4472 2021-05-25 (Android)
2021-05-25
(Linux, macOS, and Windows)
2021-06-03 (iOS) Blink 91 (except iOS) 9.1.269
  • "A number of fixes and improvements."[r 257]
  • Web apps that interact with files can now suggest file names and directories when using the File System Access API
  • The user can read files from the clipboard
  • If the website has more than one domain, and they share the same account management backend, the user can tell Chrome they're the same, allowing the password manager to suggest the right credentials
  • Web Transport-previously called Quic Transport has undergone a number of changes and is starting a new origin trial
  • Web Assembly SIMD has finished its origin trial and is available to all users
  • The <link> element's media attribute will be honored for link rel="icon", meaning the user can define different icons based on media queries[r 258]

Android version:

  • "Stability and performance improvements."[r 259]
  • The refreshed form elements have finally landed on Android, improving the user experience

iOS version:

Tab Grid View can no longer be disabled[r 261]92.0.4515 2021-07-20 (iOS)
2021-07-20
(Linux, macOS, and Windows)
2021-07-20 (Android) Blink 92 (except iOS) 9.2.230

Android version:

iOS version:

  • Users can take a screenshot of the whole webpage, then look for the "Full Page" option at the top of the screenshot editor
  • Users can add more security to their Incognito tabs with Touch ID, Face ID, or a Passcode
  • New Discover design on the New Tab Page makes exploring interests easier
  • The ability to ask for confirmation if users want to close all tabs from the Tab Switcher
  • Users can share, bookmark, and add individual tabs to their reading list from the Tab Switcher
  • Stability and performance improvements.[r 265]
  • Final version for iOS 12
93.0.4577 2021-08-31 (iOS)
2021-08-31
(Linux, macOS, and Windows)
2021-08-31 (Android) Blink 93 (except iOS) 9.3.345
  • "A number of fixes and improvements."[r 266]
  • Users can now load CSS style sheets with import statements, just like JavaScript modules
  • Installed PWAs can register as URL handlers, making it possible for users to jump straight into their PWA
  • The Multi-Screen Window Placement API has been updated based on feedback and starts a second origin trial
  • Shortened release cycle
  • Flexbox and flexbox items have added support for the alignment keywords: start, end, self-start, self-end, left, and right
  • The async clipboard API now supports SVG files
  • The media attribute will be honored when setting meta theme-color[r 267]
  • Blocked ports 989 and 990
  • Removal of 3DES in TLS
  • Deprecation of WebAssembly cross-origin module sharing[r 268]

Android version:

iOS version:

  • Updated context menu when users tap and hold a link or image in a web site
  • Users already signed in to a Google Account can now sign in more easily to Chrome and other Google Opera 55.0 Build - Crack Key For U on the web
  • Signed-in users can now both use and save payment methods from their Google Account, without sync
  • Stability and performance improvements[r 270]
  • Final version for iOS 13
94.0.4606 2021-09-21 (iOS)
2021-09-21
(Linux, macOS, and Windows)
2021-09-21 (Android) Blink 94 (except iOS) 9.4.146
  • "A number of fixes and improvements."[r 271]
  • The default color space for <canvas> elements is now formally defined in the spec as SRGB, and users can change it to Display P3
  • WebCodecs is a new, low level way to access built in audio and video codecs, important for streaming games, video editors, and such
  • WebGPU starts its origin trial
  • The prioritized scheduler.postTask() method allows users to schedule tasks, and dynamically change their priorities, or cancel them all together
  • The scrollbar-gutter property provides control over the presence of scrollbar gutters, allowing users to prevent layout changes as content expands
  • Virtual keyboard API gives users more control over how and when the virtual, on-screen keyboard is shown[r 272]
  • Deprecation and removal of WebSQL in third-party contexts
  • Restriction of private network requests for subresources to secure contexts[r 273]

Android version:

iOS version:

  • Users can now act on multiple tabs at once
  • Stability and performance improvements[r 275]
  • Now requires iOS 14
95.0.4638 2021-10-19 (iOS)
2021-10-19
(Linux, macOS, and Windows)
2021-10-19 (Android) Blink 95 (except iOS) 9.5.172
  • "A number of fixes and improvements."[r 276]
  • Routing gets easier with URLPattern baked into the browser
  • The Eye Dropper API provides a built in tool for selecting colors
  • There's a new origin trial that allows users to opt into receiving the reduced UA string now
  • The PWA Summit videos are all online
  • For users following the Opera 55.0 Build - Crack Key For U Foundation API work, there's a new origin trial for Access Handles
  • WebAssembly now provides exception handling support, which allows code to break control flow when an exception is thrown[r 277]
  • Removal of FTP support
  • Support for URLs with non-IPv4 hostnames ending in numbers
  • Deprecation of WebAssembly cross-origin module sharing
  • Deprecation of U2F API (Cryptotoken)[r 278]

Android version:

iOS version:

  • Users can now download .mobileconfig files
  • Stability and performance improvements[r 280]
96.0.4664 2021-11-09 (iOS)
2021-11-15
(Linux, macOS, and Windows)
2021-11-15 (Android) Blink 96 (except iOS) 9.6.180
  • "A number of fixes and improvements."[r 281]
  • Manifest id for PWAs
  • URL protocol handlers for PWAs
  • Priority hints Windows 10 Pro Product key Generator trial)
  • Emulation of Opera 55.0 Build - Crack Key For U 100 in the UA string
  • Chrome Dev Summit
  • The Back, forward cache – or bfcache – is now available in stable, and brings Chrome in line with both Firefox and Safari[r 282]
  • Deprecation of "basic-card" method of PaymentRequest API[r 283]

Android version:

iOS version:

97.0.4692 2021-11-10 (iOS)
2021-11-18
(Linux, macOS, and Windows)
2021-11-18 (Android) Blink 97 (except iOS) 9.7 Current Beta channel 98.0 2021-11-09 (iOS)
2021-11-18 (Android) Blink 98 (except iOS) 9.8 Current Dev channel 98.0 2021-11-06
(macOS and Windows)
2021-11-06 (Android) Blink 98 9.8 Current Canary channelMajor version Release date Layout engine[r 1]V8 engine[r 2]Significant changes Issues/Bugs
Источник: https://en.wikipedia.org/wiki/Google_Chrome_version_history

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